Study of Lipid Peroxidation-antioxidant Defense Systems in Rats under Radiation Exposure
Okassova A.K. Britko V. Okassov D.B. Tatina Y.S. Tolegenova A.I. Kuvatbaeva K.N. Kaliyeva G.T. Zhunussova M. Duzbaeva N.
1 January 2022Scientific Foundation SPIROSKI
Open Access Macedonian Journal of Medical Sciences
2022#10236 - 239 pp.
BACKGROUND: Radiation exposure is one of the factors affecting the increased formation of free radicals. Evaluation of lipid peroxidation products is very important for determining the role of oxidative damage in the pathophysiology of various diseases. AIM: The aim of the study was to study the effect of radiation at a dose of 6 Gy on the parameters of lipoperoxidation and the antioxidant system (AOS) in experimental rats. MATERIAL AND METHODS: The work was carried out on 20 male Wistar rats weighing 240 ± 20 g. Experimental animals are divided into two groups: I-normal group; II-group exposed to γ-rays at a dose of 6 Gy. The content of lipoperoxidation products was determined in all animals, diene conjugates (DC) and malondialdehyde (MDA) and AOS glutathione reductase (GLR) and glutathione peroxidase (GlP), catalase (CAT) the activity of enzymes in peripheral blood lymphocytes and in the liver, spleen, the lymph nodes, adrenal glands, and thymus. RESULTS: This study showed that the effect of ionizing radiation led to an increase in the level of DC and MDA, inhibition of the activity of CАT and GLP, GLR enzymes in almost all the studied objects, as a result of which the development of oxidative stress was observed in them. The results of the study indicate serious changes in the lipid peroxidation and AOS under radiation stress. CONCLUSION: Based on the results obtained, it was found, that irradiation increases the intensity of the formation of POL products and their accumulation, reduces the activity of enzymes of the AOS in immunocompetent organs in irradiated animals, as a result, the lack of the AOS causes oxidative stress in the body.
Antioxidant system , Catalase , Lipid peroxidation products , Radiation
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Department of Biological Sciences, L.N. Gumilyov, Eurasian National University, Nur-Sultan, Kazakhstan
Department of Biomedicine, Karaganda Medical University, Karaganda, Kazakhstan
Department of Pharmaceutical Disciplines and Chemistry, School of Pharmacy, Karaganda Medical University, Karaganda, Kazakhstan
Department of Zoology, E.A. Buketov, Karaganda University, Karaganda, Kazakhstan
Department of Biological Sciences
Department of Biomedicine
Department of Pharmaceutical Disciplines and Chemistry
Department of Zoology
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