INTRODUCTION OF MODERN RESOURCE-SAVING TECHNOLOGIES AT PHARMACEUTICAL ENTERPRISES (LEAN MANUFACTURING APPROACHES)
УПРОВАДЖЕННЯ СУЧАСНИХ РЕСУРСОЗБЕРЕЖУВАЛЬНИХ ТЕХНОЛОГІЙ НА ФАРМАЦЕВТИЧНИХ ПІДПРИЄМСТВАХ (ПІДХОДИ ОЩАДЛИВОГО ВИРОБНИЦТВА)
Nysankulov A. Seitova Z. Daulbayeva A. Ashirov M. Rakhymbayev N. Zhakipbekov K.
2025V.I. Vernadsky Taurida National University
Phytotherapy Journal
2025#2025Issue 4223 - 234 pp.
Actuality. Pharmaceutical companies are challenged to improve efficiency, reduce costs, and comply with strict regulatory requirements. Lean manufacturing approaches are considered an effective way to save resources, optimize processes, and improve quality continuously. Aim of the study is analyzes of the theoretical foundations of lean manufacturing for determining of the key stages of implementation at the pharmaceutical enterprises. Material and methods. The study was conducted in two stages: a review of domestic and foreign literature for 2000–2025 using Google Scholar, PubMed, Scopus, and Web of Science searches for relevant keywords; analytical summary of pharmaceutical manufacturing practices with a focus on production processes, quality control systems, loss reduction methods, and resource conservation strategies. At the second stage of the study, pharmaceutical production processes, quality control systems, loss reduction methods and resource-saving strategies were analyzed. Research results. A six-step implementation sequence has been identified: diagnosis and goal setting; mapping and analysis of losses; development and implementation of improvements; staff training and Kaizen culture development; monitoring and corrective actions; final assessment. It has been shown that integrating Lean with digital technologies enhances quality control and flexibility. According to the case studies reviewed, quality control reliability increased by more than 50%, inventory and defects were reduced by approximately 57%, throughput increased, and work in progress decreased. Three implementation scenarios (maximum, moderately optimal, “soft”) are proposed, describing the limitations and risks for companies with varying degrees of readiness. Conclusion. Lean manufacturing, enhanced by digital tools, reduces losses, inventory, and defects, speeds up processes, and improves the quality and productivity of pharmaceutical production. In the context of rising costs, stricter standards and environmental requirements, it is becoming a strategic factor of competitiveness, especially for developing countries. For the first time, a standard Lean manufacturing implementation plan has been proposed with three scenarios – “maximum”, “moderate-optimal” and “soft”, which allows flexible strategy selection depending on resources. The results can be applied to the implementation of Lean manufacturing in pharmaceutical enterprises, in particular The Republic Kazakhstan.
efficiency improvement , Lean Manufacturing , pharmaceutical manufacturing , process optimisation , resource efficiency
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Department of Organization, Management and Economics of Pharmacy and Clinical Pharmacy, S.D. Asfendiyarov Kazakh National Medical University, Tole Bi, 94, Almaty, 050000, Kazakhstan
Department of Engineering Disciplines and Good Practices, S.D. Asfendiyarov Kazakh National Medical University, Tole Bi, 94, Almaty, 050000, Kazakhstan
Department of Organization
Department of Engineering Disciplines and Good Practices
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026