Associative Effects of the Il-8 and Il-17a Genes on Reproductive Function and the Occurrence of Lethal Mutations in Cows
Nurpeissova R. Yergazina M. Ryspekova S. Buralkhiyev B. Aitzhanov B. Muratbaev A. Bagdat A. Ussenbekov Y.
Mar-Apr 2025Unique Scientific Publishers
International Journal of Veterinary Science
2025#14Issue 2251 - 259 pp.
In this work, single-nucleotide polymorphisms (SNPs) in the II and III exon parts of the interleukin-8 (IL-8) gene and the II exon part of IL-17 (SNP c.126G>A) were studied. The effects of IL-17A gene alleles on the reproductive ability of Holstein cows (n=164, Medeu Commerce LLP) were determined. This study revealed the absence of genetic polymorphisms at the IL-8 gene locus, where carriers of only homozygous AA genotypes for both SNPs were identified. Concerning the IL-17A gene locus (SNP c.126G>A), an excessive occurrence of the heterozygous AG genotype (+15,622 specimens) was observed. Cows successfully inseminated within 45–60 and 61–90 days after calving most often had the IL-17A gene locus with homozygous GG genotypes (50.0 and 25.0%). In this group of animals, 8.06 and 19.5% had the homozygous AA genotype, and 7.77 and 25.55% had the heterozygous AG genotype. On the basis of these results, the authors believe that the G allele positively correlates with high reproductive ability in Holstein cows. The IL-17A polymorphism (SNP c.126G>A) can be used as a DNA marker of reproductive function. In cows of the Holstein breed at Mezhdurechensk AGRO LLP (n=150) and in stud bulls of Holstein and black-and-white breeds at Asyl Tulik JSC (n=37), the prevalence of the fertility haplotype was 4.67% and 5.40%, respectively, and the complex vertebral malformation hereditary anomalies occurred in 7.33% and 8.10%, respectively. The polymerase chain reaction-restriction fragment length polymorphism and real-time polymerase chain reaction methods confirmed the high diagnostic effectiveness during genetic screening. Thus, according to the existing international strategy for eliminating harmful mutations in breeding animals, examining 10–20% of livestock for carriers of genetic defects is recommended.
Complex vertebral malformation , Fertility haplotype HH6 , Genetic monitoring , Real-time polymerase chain reaction , Reproductive function of cows
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Kazakh National Agrarian Research University, Kazakhstan
Asfendiyarov Kazakh National Medical University, Kazakhstan
Kazakh Research Veterinary Institute, Kazakhstan
Marat Ospanov West Kazakhstan Medical University, Kazakhstan
Kazakh National Agrarian Research University
Asfendiyarov Kazakh National Medical University
Kazakh Research Veterinary Institute
Marat Ospanov West Kazakhstan Medical University
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