Combined Computational and Experimental Study of Inclusion Complexes of Lupinine and its 1,2,3-triazole Derivative with β-cyclodextrin
Nurmaganbetov Z.S. Fazylov S.D. Nurkenov O.A. Sarsenbekova A.Zh. Pustolaikina I.A. Seilkhanov O.T. Sviderskiy A.K. Minayeva Y.V.
8 July 2025Institute of Combustion Problems, al-Farabi Kazakh State National University
Eurasian Chemico-Technological Journal
2025#27Issue 2127 - 138 pp.
The study presents the results of obtaining clathrate inclusion complexes of the alkaloid lupinine (Lup) and its 1,2,3-triazole derivative (Lup-T) using the oligosaccharide β-cyclodextrin (β-CD). The structural features of the encapsulated forms of lupinine (Lup) and its derivatives were characterized by molecular modeling, IR spectroscopy,1H and13C NMR, as well as two-dimensional1H-1H (COSY) and1H-13C (HMBC, HSQC) NMR spectroscopy. A comparative thermal degradation study of lupinine, its triazole derivative, and their inclusion complexes with β-cyclodextrin was performed using differential thermogravimetry (DTG) and differential scanning calorimetry (DSC). The kinetic parameters of the thermal decomposition reactions of lupinine-based substrates at different heating rates, along with the values of apparent activation energy, were calculated using model-free isoconversional methods by Friedman and Ozawa-Flynn-Wall.
1,2,3-triazoles , Inclusion complexes , Lupinine alkaloid , Quinolizidine derivatives , β-cyclodextrin
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Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Alikhanov str., 1, Karaganda, Kazakhstan
Karaganda Medical University, Gogol str., 40, Karaganda, Kazakhstan
Karaganda Buketov University, Universitetskaya str., 28, Karaganda, Kazakhstan
Kokshetau University of the name of Sh. Ualikhanov, Abay St., 76, Kokshetau, Kazakhstan
Department of Mining, Metallurgy and Natural Sciences, Zhezkazgan University named after O. Baikonurov, Alashakhan ave., 1b, Zhezkazgan, Kazakhstan
Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan
Karaganda Medical University
Karaganda Buketov University
Kokshetau University of the name of Sh. Ualikhanov
Department of Mining
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