Biosensors and enabling analytical technologies for in vitro fertilization: current trends and emerging applications
Nurlankyzy M. Oladejo T.O. Seipetdenova S. Seitkamal K. Ashikbayeva Z. Koyanbayeva D. Myrkhiyeva Z. Abdossova A. Bekmurzayeva A. Tosi D.
June 2026Elsevier B.V.
TrAC - Trends in Analytical Chemistry
2026#199
Infertility affects more than 18% of people worldwide. In vitro fertilization (IVF) is the primary assisted reproductive technology. However, the effectiveness of the procedure is still limited by the low level of implantation, high cost, and significant physical and emotional stress for patients. In recent years, significant progress has been made in developing biosensor technologies capable of providing highly sensitive, continuous, and non-invasive monitoring of biomarkers throughout all stages of IVF. This review examines modern sensory platforms, their mechanisms of action, sensitivity limits, and potential clinical value for assessing ovarian reserve, monitoring hormonal profile, diagnosing endometriosis and ovarian cancer, and evaluating gamete and blastocyst quality. Moreover, microfluidic technologies for high-precision sperm selection, non-invasive embryo assessment methods, including slow-motion imaging systems, and optical approaches, and the integration of artificial intelligence algorithms for automated embryo selection and outcome prediction, are presented. It is expected that the combination of biosensors, microfluidic technologies, other enabling analytical platforms, and artificial intelligence could improve the accuracy of hormonal monitoring, individualize stimulation, improve embryo selection, and increase the likelihood of pregnancy and live birth. Together, these technologies form the basis for transitioning to more accurate, affordable, and personalized IVF protocols.
Biomarkers , Endometriosis , Hormones , In vitro fertilization , Optical fiber biosensors
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Laboratory of Biosensors and Bioinstruments, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan
School of Engineering and Digital Sciences, Nazarbayev University, Astana, Kazakhstan
School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan
Laboratory of Biosensors and Bioinstruments
School of Engineering and Digital Sciences
School of Sciences and Humanities
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Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026