Synthesis and Antimicrobial Activity of Phthalide Derivatives of Cytisine, Anabasine, and Salsoline
Nurkenov O.A. Fazylov S.D. Nurmaganbetov Z.S. Seilkhanov T.M. Seidakhmetova R.B. Muldakhmetov Z.M. Gazaliev A.M.
November 2023Springer
Chemistry of Natural Compounds
2023#59Issue 61147 - 1150 pp.
Aminophthalide derivatives of cytisine, anabasine, and salsoline were obtained in high yields via condensation of the alkaloids with o-formylbenzoic acid. Their structures were proven using 1H and 13C NMR spectroscopy and data from 2D COSY 1H–1H and HMQC 1H–13C spectra. Studies of their antimicrobial activity showed moderate antimicrobial activity of 3-(N-cytisin-1-yl)isobenzofuran-1(3H)-one and 3-(N-salsolin-1-yl)isobenzofuran-1(3H)-one against Gram-positive test strain Staphylococcus aureus ATCC 6538 and Gram-negative test strain Escherichia coli ATCC 25922.
alkaloids cytisine , aminophthalide , anabasine , antimicrobial activity , NMR spectroscopy , o-formylbenzoic acid , salsoline
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Institute of Organic Synthesis and Coal Chemistry, Republic of Kazakhstan, 1 Alikhanov St, Karaganda, 100008, Kazakhstan
Karaganda Medical University, 40 Gogol St, Karaganda, 100012, Kazakhstan
Sh. Ualikhanov Kokshetau University, 76 Abay St, Kokshetau, 020000, Kazakhstan
Institute of Organic Synthesis and Coal Chemistry
Karaganda Medical University
Sh. Ualikhanov Kokshetau University
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