Long-Term Outcomes of Endovascular Embolization in a Vein of Galen Aneurysmal Malformation: A Single-Center Experience

Nurimanov C. Makhambetov Y. Menlibayeva K. Nurakay N. Makhambetov N. Zholdybayeva E. Akshulakov S.
August 2023 Multidisciplinary Digital Publishing Institute (MDPI)

Diagnostics
2023 #13 Issue 16

Background: A vein of Galen aneurysmal malformation (VGAM) is a rare congenital cerebral vascular condition with a high mortality rate if left untreated. This study describes the long-term outcomes of patients with VGAM, who were treated with endovascular embolization. Methods: This retrospective analysis focused on VGAM patients who underwent one or more endovascular embolization sessions between January 2008 and December 2022. The study included newborns and children under 18 years. Data encompassed clinical and demographic characteristics, types of endovascular embolization, treatment complications, mortality rates, and long-term outcomes. Results: Out of 22 VGAM cases, the majority were boys (86.36%), and the average age of the participants was 38 months, ranging from 25 days to 17 years. Endovascular embolization using liquid embolizing agents was the most common intervention (50%), and around 73% of patients underwent multiple sessions. Some patients underwent ventriculoperitoneal shunting (VPS) due to persistent hydrocephalus. In long-term outcomes, four patients (18.2%) showed developmental delays, and 16 patients (72.7%) had a positive outcome. Conclusions: Combining endovascular therapy with a comprehensive management strategy significantly reduces mortality rates and improves the possibility of normal neurological development in patients.

AV malformation of the vein of Galen , Bicêtre score , endovascular embolization , hydrocephalus , neonates , the vein of Galen aneurysmal malformation

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Vascular and Functional Neurosurgery Department, National Center for Neurosurgery, Astana, 010000, Kazakhstan
Hospital Management Department, National Center for Neurosurgery, Astana, 010000, Kazakhstan
National Scientific Shared Laboratory, National Center for Biotechnology, Astana, 010000, Kazakhstan

Vascular and Functional Neurosurgery Department
Hospital Management Department
National Scientific Shared Laboratory

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