Identification of genetic variants the CCKAR gene and based on body measurement and carcass quality characteristics in Qinchuan beef cattle (Bos taurus)

Nurgulsim K. Raza S.H.A. Khan R. Shah M.A. Jahejo A.R. Batool U. Hongbao W. Zhigerbayevich K.N. Schreurs N. Zan L.
May 2021 Pontificia Universidad Catolica de Valparaiso

Electronic Journal of Biotechnology
2021 #51 1 - 7 pp.

Background: This study aimed to explore genetic polymorphisms of the CCKAR gene and their relationship with the growth and development of Qinchuan cattle which could be used as molecular markers for the improvement of the breeding of Qinchuan cattle. Results: Here, we have identified seven single nucleotide polymorphisms (SNPs) at loci g. 1463 C>G; g. 1532 T>A; g. 1570 G>A; g. 1594 C>A; g. 1640 T>C; g. 1677 G>C; and g. 1735 C>T in the coding region of the bovine CCKAR gene. The frequencies identified on allelic and genotypic characteristics have shown that all seven SNPs diverged from the Hardy-Weinberg-Equilibrium. The SNP2, SNP3, SNP6 and SNP7 had the lowest polymorphism information content values, and remaining SNPs were found to be moderate (0.25 < PIC < 0.50). The genotype CG in SNP1 at loci g.1463 C>G had the greatest association with WH, HW, CD and CCF, while the genotype TA at the very same loci was associated with BFT, ULA and IMF content in Qinchuan cattle. The CCKAR gene expression level in adipose tissue, small intestine, liver and skeleton muscle was found to be higher, whereas, the expression level of mRNA in organs of other digestive system including reticulum, abomasum and omasum was moderate. Some expression of CCKAR mRNA was found in the large intestine, kidney and rumen. Conclusion: In summary, our finding suggested that the CCKAR gene could be used as a potential candidate for the improvement of carcass quality and body measurements of Qinchuan cattle. How to cite: Nurgulsim K, Raza SHA, Khan R, et al. Identification of genetic variants the CCKAR gene and based on body measurement and carcass quality characteristics in Qinchuan beef cattle (Bos taurus). Electron J Biotechnol 2021;51. https://doi.org/10.1016/j.ejbt.2021.02.001

Body measurement , Bos taurus , Carcass , Cattle , CCKAR gene , Digestive system , Expression pattern analysis , Qinchuan beef cattle , SNP

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State Key Laboratory of Animal Genetics Breeding & Reproduction, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China
Department of Livestock Management, Breeding and Genetic, The University of Agriculture Peshawar, Pakistan
University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zatisi 728/II, Vodnany, 389 25, Czech Republic
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, China
Department of Microbiology Shaheed Benazir, Bhutto Women University Peshawar, Pakistan
Faculty of Veterinary and Livestock Technology, S. Seifullin Kazakh Agrotechnical University, Kazakhstan
Animal Science, School of Agriculture and Environment, Massey University, Private Bag 11222, Palmerston North, New Zealand
National Beef Cattle Improvement Center, Northwest A&F University, Yangling, 712100, Shaanxi, China

State Key Laboratory of Animal Genetics Breeding & Reproduction
Department of Livestock Management
University of South Bohemia in Ceske Budejovice
College of Animal Science and Veterinary Medicine
Department of Microbiology Shaheed Benazir
Faculty of Veterinary and Livestock Technology
Animal Science
National Beef Cattle Improvement Center

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