Post treatment improvement of laryngopharyngeal refludiagnosed using a novel algorithm: A cohort study
Nukusbekova G. Toguzbayeva D. Oguz H. Hashimli R. Taukeleva S. Kaldybayev D. Karibayeva I.
29 October 2024Mattioli 1885
Acta Biomedica
2024#95Issue 5
Purpose: To compare pre-and post-treatment measurements in patients diagnosed with laryn-gopharyngeal reflux (LPR), and to compare patients with gastroesophageal reflux disorder (GERD) who exhibit symptoms of laryngopharyngeal reflux to those who do not, using a combined algorithm. Methods: This prospective cohort study involved 384 patients and used the following algorithm: a Reflux Symptom Index (RSI) questionnaire score of >13, videolaryngostroboscopy with an assessment of the Reflux Finding Score (RFS) >7, pH strips of mucus from the laryngopharynx, and acoustic analysis of the voice in singers with voice disorders. Patients with LPR and GERD were treated with proton pump inhibitors at a dose of 20 mg twice a day and were given lifestyle and dietary changes recommendations for one month. The patients were monitored for six months. Results: After treatment, RSI and RFS results in patients with LPR and GERD significantly improved from 19.9±6.4 & 9.1±1.7 and 18.7±5.3 & 10.10±2.4 respectively (p<0.001). In patients without the symptoms of LPR, the laryngopharyngeal medium pH ranged from min 5.5 to max 7.5, and in cases of suspected LPR and GERD, it ranged from min 5 to max 8 and min and 4.5 to max 8.5 respectively. The acoustic voice analysis scores changed after therapy, p-value<0.05. Conclusion: The lack of a gold standard and the inaccessibility of diagnostic methods make LPR diagnosis a very complex task. However, using the proposed diagnostic algorithm, the post treatment scores were improved. More studies are needed to validate the algorithm for early diagnosis of LPR. (www.actabiomedica.it).
acoustic voice anapH indicator , laryngopharyngeal reflux , reflux finding score , reflux symptom index
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Department of Otorhinolaryngology, Kazakh-Russian Medical University, Almaty, Kazakhstan
Department of Otolaryngo-logy, Lokman Hekim Universitesi, Ankara, Turkey
Department of Otorhinolaryngology, Azerbaijan State Advanced Training Institute for Doctors named after Aziz Aliyev Baku, Azerbaijan
Department of Otorhinolaryngology, Almaty City Clinical Hospital N5, Almaty, Kazakhstan
Department of Health Policy and Community Health, Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, GA, United States
Department of Otorhinolaryngology
Department of Otolaryngo-logy
Department of Otorhinolaryngology
Department of Otorhinolaryngology
Department of Health Policy and Community Health
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