Efficacy and Safety of Intracavernous Administration of Platelet-Rich Plasma in the Treatment of Erectile Dysfunction in Kazakh Population: Results of a Six-Month Follow-Up

Nugumanov R. Omarbayev R. Iskakov Y. Suchshenko A. Yermaganbetov Y. Akhmetkaliyev D. Manarbek A. Baigenzhin A.
2025 National Scientific Medical Center

Journal of Clinical Medicine of Kazakhstan
2025 #22 Issue 5 58 - 65 pp.

Erectile dysfunction (ED) is a common problem that can affect men of all ages and has a significant impact on mental and physical health and overall quality of life. In Kazakhstan, among 1,550 examined men (aged 21 to 79), 784 were diagnosed with ED (52.3%). In recent years, with the development of gene and regenerative technologies, a new promising strategy for the treatment of organic forms of ED has emerged: transplantation of mesenchymal stem cells obtained f rom bone marrow and mesenchymal stromal cells obtained f rom adipose tissue. Autologous platelet-rich plasma (PRP) contains platelet concentrations three to seven times higher than physiological norms and is rich in growth factors, chemokines, and angiogenic factors. Therefore, a prospective study was conducted in a Kazakh population to investigate the safety and efficacy of intracavernous PRP injections in patients with moderate to severe ED. The use of PRP therapy for the treatment of moderate and severe ED is safe but weakly effective. The activation of PRP with calcium chloride did not yield any particular results. Therefore, higher dosages may be associated with better short-term results. The PRP therapy technique requires further careful study and development of standards for the use of PRP in clinical practice, especially for the treatment of severe and moderate forms of ED. Additional prospective and randomized placebo-controlled trials are needed to finally assess the effectiveness of PRP therapy in improving erectile function.

erectile dysfunction , intracavernous injections , platelet-rich plasma

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Medi-Art Clinic, Astana, Kazakhstan
Department of Urology, JSC “National Scientific Medical Center”, Astana, Kazakhstan
Department of urology and andrology, JSE «Astana Medical University», Astana, Kazakhstan
Institute of Fundamental and Applied Medicine, JSC “National Scientific Medical Center”, Astana, Kazakhstan
Chairman of the Board, JSC National Scientific Medical Center, Astana, Kazakhstan

Medi-Art Clinic
Department of Urology
Department of urology and andrology
Institute of Fundamental and Applied Medicine
Chairman of the Board

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