Preclinical atherosclerosis in cystic fibrosis: Two distinct presentations are related to pancreatic status

Nowak J.K. Wykrętowicz A. Mądry E. Krauze T. Drzymała-Czyż S. Krzyżanowska-Jankowska P. Sobkowiak P. Schneider A. Goździk-Spychalska J. Kurek S. Kononets V. Kashirskaya N. Lisowska A. Walkowiak J.
January 2022 Elsevier B.V.

Journal of Cystic Fibrosis
2022 #21 Issue 1 26 - 33 pp.

Background: Patients with cystic fibrosis (CF) are exposed to overlapping cardiovascular risk factors. We hypothesized that CF is characterized by increased arterial stiffness and greater intima-media thickness (IMT). Methods: This cross-sectional study assessed the digital volume pulse arterial stiffness index (SI_DVP) using photopletysmography, measured intima-media complex thickness (IMT) at the common carotid artery, and obtained an extended set of clinical and atherosclerosis-related laboratory parameters. Results: Fifty-five patients with moderate-to-severe CF (mean age 26.3±8.6 years, BMI 20.3±3.1 kg/m2, FEV1 62±26%) and 51 healthy controls (25.1±4.4 years, BMI 21.7±3.0 kg/m2) entered the study. SI_DVP was greater in pancreatic insufficient (PI), but not pancreatic sufficient (PS) CF patients compared with control (7.3±1.8 m/s vs 6.0±1.2 m/s; p=7.1 × 10⁻⁵). IMT was increased in PS (but not PI) participants relative to control (552±69 µm vs 456±95 µm, p=0.0011). SI_DVP was also greater in PI than in PS patients (7.3±1.8 m/s vs 6.3±1.7 m/s, p=0.0232) and IMT was higher in PS compared with PI (552±69 µm vs 453±82 µm, p=0.0002). SI_DVP independently associated with age, PI, the lack of liver cirrhosis, and with Pseudomonas aeruginosa colonization. PS was the only independent correlate of IMT in CF. Conclusions: PI patients are at risk of developing general arterial stiffness. PS may relate to carotid IMT thickening, which underscores the need for further study that could lead to reconsideration of dietary guidance in PS CF.

Arterial stiffness , Atherosclerosis , Cystic fibrosis , Digital volume pulse , Intima-media , Lipids

Text of the article Перейти на текст статьи

Poznan University of Medical Sciences, Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan, Poland
Poznan University of Medical Sciences, Department of Cardiology-Intensive Therapy, Poznan, Poland
Poznan University of Medical Sciences, Department of Physiology, Poznan, Poland
Poznan University of Medical Sciences, Department of Bromatology, Poznan, Poland
Poznan University of Medical Sciences, Department of Pediatric Pneumonology, Allergology and Clinical Immunology, Poznan, Poland
Poznan University of Medical Sciences, Department of Pulmonology, Allergology and Respiratory Oncology, Poznan, Poland
West Kazakhstan Marat Ospanov Medical University, Department of Natural Sciences Disciplines, Aktobe, Kazakhstan
Research Centre for Medical Genetics, Department of Genetic Epidemiology, Cystic Fibrosis Group, Moscow, Russian Federation

Poznan University of Medical Sciences
Poznan University of Medical Sciences
Poznan University of Medical Sciences
Poznan University of Medical Sciences
Poznan University of Medical Sciences
Poznan University of Medical Sciences
West Kazakhstan Marat Ospanov Medical University
Research Centre for Medical Genetics

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026