Applications and Advancements of Animal Cell Cultures in Virology: Insights from Lumpy Skin Disease Virus Research
Nissanova R. Molla W. Orynbayev M. Serikov M. Kirpichenko V. Ragatova A. Kassenov M. Bizhanov A. Kassymbekova L. Zhanabayev A. Baikadamova G. Abutalip A. Mussayeva A. Omarbekova U. Ospanov Y. Tlegenova Z. Borsynbayeva A. Turgenbayev K. Mussoyev A. Berdikulov M. Aheti B. Alymov I.
September-October 2025Unique Scientific Publishers
International Journal of Veterinary Science
2025#14Issue 5846 - 853 pp.
The article provides a comprehensive review of the current state and future directions for the use of animal cell cultures in virological research. The review critically evaluates the use of animal cell cultures to enhance understanding of viral pathogenesis and improve vaccine development strategies, highlighting promising technologies in this field. It discusses technologies and tools for virus and cell visualization, bioinformatics approaches to data analysis, and the challenges and potential for future research. The review emphasizes the importance of animal cell cultures in studying viruses and developing vaccines, noting the advent of 3D cell culture technologies that enhance the translational significance of in vitro models. The adaptation of new culture media mimicking human blood plasma is expected to improve understanding of viral pathogenesis and virus propagation efficiency. The use of animal cell cultures is illustrated through the study of the lumpy skin disease virus. The application of artificial intelligence in cell and tissue cultivation research opens possibilities for modeling and analyzing viral pathogenesis. The article calls for further development in this area, emphasizing the need to establish a National Collection of Cell Cultures.
Animal cell cultures , Lumpy skin disease virus , Vaccine development , Virology
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Department of Bacteriology, Kazakh Research Veterinary Institute, Almaty, 050016, Kazakhstan
College of Veterinary Medicine and Animals Sciences, University of Gondar, Gondar, 196, Ethiopia
Research Institute for Biological Safety Problems, 080409, Kazakhstan
Department of Veterinary Medicine, A. Baitursynov Kostanay Regional University, 110000, Kazakhstan
Department of Veterinary Medicine and Industrial Technologies, Innovative University of Eurasia, Pavlodar, 140000, Kazakhstan
Department of Veterinary Medicine, Saken Seifullin Kazakh Agrotechnical University, Astana, 010000, Kazakhstan
Department of Biology, K. Zhubanov Aktobe Regional University, 030000, Kazakhstan
Kazakh National Agrarian Research University, Almaty, 050008, Kazakhstan
National Reference Center for Veterinary Medicine, Astana, 010000, Kazakhstan
Department of Bacteriology
College of Veterinary Medicine and Animals Sciences
Research Institute for Biological Safety Problems
Department of Veterinary Medicine
Department of Veterinary Medicine and Industrial Technologies
Department of Veterinary Medicine
Department of Biology
Kazakh National Agrarian Research University
National Reference Center for Veterinary Medicine
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