THE ROLE OF THE COMPONENTS OF THE IMMUNE SYSTEM IN PRETERM BIRTH DUE TO PLACENTAL DYSFUNCTION
Nikolaeva A.S. Tanysheva G.A. Koliado O.V. Remneva O.V. Molchanova I.V. Dyusupov A.A.
2025Bionika Media Ltd.
Akusherstvo i Ginekologiya (Russian Federation)
2025#2025Issue 479 - 84 pp.
Objective: To evaluate the role of the components of the immune system in the pathogenesis of preterm birth due to severe preeclampsia and placental abruption of normally implanted placenta. Materials and methods: A total of 80 women with induced preterm birth (the main group) were examined. The sample was divided into two subgroups. Subgroup 1 consisted of patients with abdominal delivery due to progression of severe preeclampsia. Subgroup 2 consisted of patients with preterm birth due to placental abruption of normally implanted placenta. The control group consisted of women with term uncomplicated birth. The levels of interleukin (IL)-8, IL-10, tumor necrosis factor alpha (TNF-α), human chorionic gonadotropin and pregnancy-associated plasma protein A (PAPP-A) were studied as the predictors of preterm birth. Results: It was found that IL-8, TNF-α and PAPP-A play an important role in the pathogenesis of induced preterm birth due to severe obstetric complications. Elevation of IL-8 level by 1 unit increases the risk of preterm birth by 2.96 times; elevation of TNF-α level by 1 unit increases the risk of preterm birth by 1.56 times, while elevation of PAPP-A level by 1 unit reduces the risk of adverse outcomes by 0.04 times. Conclusion: The components of the immune system play an important role in the pathogenesis of preterm birth and placental dysfunction. Research in this area expands knowledge of the mechanisms of severe obstetric complications and is important for prediction of adverse obstetric outcomes.
interleukin-8 , preeclampsia , pregnancy-associated plasma protein A , preterm birth , tumor necrosis factor alpha
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Semey Medical University, Abay str., 103, Semey, 071400, Kazakhstan
Altai State Medical University, Ministry of Health of Russia, Lenin str., 40, Barnaul, 656038, Russian Federation
Semey Medical University
Altai State Medical University
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026