Objective assessment of the damaging effect of glucocorticoids (toxicity index) in patients with systemic lupus erythematosus

Nikishina N.Yu. Ermolaeva E.V. Mesnyankina A.A. Aseeva E.A. Soloviev S.K. Isaeva B.Sh. Koylubaeva G.M. Lila A.M.
2021 Ima-Press Publishing House

Sovremennaya Revmatologiya
2021 #15 Issue 6 111 - 116 pp.

Systemic lupus erythematosus (SLE) is a multisystem disease characterized by chronic inflammation and damage to vital organs and systems. Despite the great success achieved in the treatment of SLE, glucocorticoids (GC) remain one of the main methods of therapy. The GC toxicity index is an objective method for assessing adverse events associated with their use, and in future studies can be actively used to monitor the safety of various therapy regimens. Wider introduction of this index in the management of patients with SLE will allow to optimize approaches to the selection of GC doses, to consider earlier prescription of biologic disease modifying antirheumatic drugs, before the development of severe irreversible damage.

Glucocorticoids , Irreversible organ damage , Systemic lupus erythematosus , Toxicity index

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V.A. Nasonova Research Institute of Rheumatology, 34A, Kashirskoe shosse, Moscow, 115522, Russian Federation
JSC Group of companies MEDSI, 3A, Gruzinskiy pereulok, Moscow, 123056, Russian Federation
Asfendiyarov Kazakh National Medical University, 94, Tole Bi street, Almaty, 050000, Kazakhstan
National Center for Cardiology and Therapy named after academician Mirsaid Mirrakhimov under the Ministry of Health of the Kyrgyz Republic, 3, Togoloka Moldo street, Bishkek, 720040, Kyrgyzstan
Department of Rheumatology Russian Medical Academy of Continuing Professional Education, 2/1, Barrikadnaya street, Build. 1, Moscow, 125993, Russian Federation

V.A. Nasonova Research Institute of Rheumatology
JSC Group of companies MEDSI
Asfendiyarov Kazakh National Medical University
National Center for Cardiology and Therapy named after academician Mirsaid Mirrakhimov under the Ministry of Health of the Kyrgyz Republic
Department of Rheumatology Russian Medical Academy of Continuing Professional Education

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