Application of Iron Oxide Nanoparticles as MRI Contrast Enhancers: A study in Rabbits
Nessipkhan B. Al-Saedi H.F.S. Al-saray M.J. Jasim H.H. Sattar R. Ahmed B.A. Wabdan A.K. Alyas M.A. Mavlyanova S. Khurramov A.M. Muzaffar Z.
2023University of Kashan
Journal of Nanostructures
2023#13Issue 3769 - 776 pp.
Iron oxide nanoparticles (IONPs) have been identified as a promising class of compounds that can enhance contrast in MRI (magnetic resonance imaging) scans due to their superparamagnetic properties. This study evaluates the efficacy of dextran-coated IONPs as T2 contrast agents for MRI in a rabbit model. IONPs were prepared through a co-precipitation process and subsequently coated with a layer of dextran. The nanoparticles underwent characterization using techniques such as TEM (transmission electron microscopy), vibrating sample magnetometry (VSM), and XRD (X-ray diffraction). New Zealand White rabbits (n=6) were used for in vivo MRI studies. IONPs (10 mg Fe/kg) were administered intravenously, and MRI scans (T1-and T2-weighted) were taken at baseline and at various intervals (1, 4, and 24 h) after IONP administration. Signal intensity changes and contrast enhancement were analyzed in the liver, spleen, and kidneys. The IONPs exhibited an average size of 15 ± 3 nm, an inverse spinel crystal structure, and displayed magnetic characteristics indicative of superparamagnetism with a 65 ± 5 emu/g saturation magnetization. MRI scans revealed significant signal intensity changes and contrast enhancement in the liver, spleen, and kidneys after IONP administration. The maximum contrast enhancement was observed at 4 h post-injection, with a 60 ± 8% reduction in T2 signal intensity in the liver and a 45 ± 7% reduction in the spleen. The contrast enhancement persisted up to 24 h in the liver and spleen, while the kidneys showed lower contrast enhancement and rapid clearance of the nanoparticles. In conclusion, dextran-coated IONPs demonstrated effective T2 contrast enhancement in MRI of rabbits, particularly in the liver and spleen. The prolonged retention of the nanoparticles in these organs makes them suitable for long-term imaging studies. However, the rapid clearance from the kidneys may limit their application for kidney imaging.
IONPs , Kidneys , Liver , Rabbit model , Spleen
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Institute chemikal science, KazNPU, Almaty, 050010, Kazakhstan
Faculty of pharmacy, Department of pharmaceutics, University of Al-Ameed, Iraq
Al-Manara College For Medical Sciencesz, Maysan, Iraq
Department of Medical Instrumentation Engineering Techniques, Imam Ja’afar Al-Sadiq University, Iraq
Department of Medical Instrumentation Engineering Techniques, Al-Hadi University College, Baghdad, Iraq
Department of medical engineering, Al-Nisour University College, Baghdad, Iraq
Collage of Pharmacy, National University of Science and Technology, Dhi Qar, 64001, Iraq
Department of Medical Instrumentation Engineering Techniques, Al-Zahrawi University, Iraq
Republican Specialized Scientific and Practical Medical Center for Dermatovenerology and Cosmetology, Ministry of Health of the Republic of Uzbekistan, Uzbekistan
International School of Finance and Technology, Tashkent, Uzbekistan
Fergana Medical Institute of Public Health, Uzbekistan
Institute chemikal science
Faculty of pharmacy
Al-Manara College For Medical Sciencesz
Department of Medical Instrumentation Engineering Techniques
Department of Medical Instrumentation Engineering Techniques
Department of medical engineering
Collage of Pharmacy
Department of Medical Instrumentation Engineering Techniques
Republican Specialized Scientific and Practical Medical Center for Dermatovenerology and Cosmetology
International School of Finance and Technology
Fergana Medical Institute of Public Health
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