ГЕНЕТИЧЕСКИЕ ПРЕДИКТОРЫ ШИЗОФРЕНИИ И ИХ ОСОБЕННОСТИ В ОТДЕЛЬНЫХ ЭТНИЧЕСКИХ ПОПУЛЯЦИЯХ (обзорная статья)
GENETIC PREDICTORS OF SCHIZOPHRENIA AND THEIR FEATURES IN INDIVIDUAL ETHNIC POPULATIONS (REVIEW ARTICLE)
Negay N.A. Altynbekov K.S. Raspopova N.I. Abetova A.A. Yessimov N.B.
October 2022Georgian Association of Business Press
Georgian Medical News
2022#331Issue 106 - 11 pp.
The paper presents a review of current literature data on ongoing international studies to identify genetic predictors of schizophrenia, since heredity and family predisposition to schizophrenia have been known for several decades. New data on the interaction between genetic variants, epigenetic marks, including cross interaction between the processes of DNA methylation and histone modification, affecting the regulation of gene expression under the influence of the environment, are reflected. Particular attention is paid to studies devoted to identifying the features of genetic predictors of schizophrenia in certain ethnic populations, in particular in relation to persons of the Kazakh ethnic group in the Republic of Kazakhstan. The study was carried out within the framework of the project: National program for the introduction of personalized and preventive medicine in the Republic of Kazakhstan IRN OR12165486.
epigenome , ethnocultural features , genetics , Kazakh population , Schizophrenia
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World Health Organization Country Office in Kazakhstan, Astana, Kazakhstan
Republican Scientific and Practical Center for Mental Health, Almaty, Kazakhstan
Kazakh National Medical University named after S.D. Asfendiyarov, Almaty, Kazakhstan
World Health Organization Country Office in Kazakhstan
Republican Scientific and Practical Center for Mental Health
Kazakh National Medical University named after S.D. Asfendiyarov
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