Deer antler extract-nanoparticles exhibit co-nanozyme activity and targeting of prostate cancer cells
Nazarbek G. Mu C. Shaimoldina A. Omarova Z. Toktarov N. Wang L.-X. Ahmad A. Zeitkaziyeva D. Fan H. Shi L. Chen Z. Xie Y.
April 2024Elsevier Ltd
Journal of Functional Foods
2024#115
Deer antler extract contains chemical compounds and peptides which have been shown to exert many pharmacological functions. However, the extract may also exhibits potential particle characteristics at nanoscale thereby acting as intrinsic nanozyme upon processing. We aim to test the nanoscale effect on cancer cells. We found that the water extract contains nanoscale particles characterized by SEM, TEM, AFM, zeta potential, and exhibits nanozyme or co-nanozyme activities of phosphatase, catalase which has crosstalk associated with anti-prostate cancer cells viability, especially with combined inhibitor of MET kinase by co-targeting phosphorylation. Network pharmacology analysis also showed immune mechanisms. Docking analysis shows the potent antler extract compound mediated inhibition of MET kinase. Nanoscale particles and compounds from antler extract at least in part, contribute to anticancer mechanisms which would be a promising combination agent in anti-cancer via nanotechnology.
Antler extract , Co-nanozyme , Nanoparticles , Nanozyme
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Department of Biology, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan
ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou, China
Kazakh Scientific Research Institute of Maral Husbandry, Beekeeping and Organic Agricultural Technologies, LLP, Ust-Kamenogorsk, Kazakhstan
Heze Academy of Agricultural Sciences, Heze, 274000, China
Department of Bioinformatics, Hazara University, KPK, Mansehra, 21300, Pakistan
School of Medicine, Nazarbayev University, Astana, Kazakhstan
Department of Chemistry, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan
Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College, Nashville, TN, United States
Department of Biology
ZJU-Hangzhou Global Scientific and Technological Innovation Center
Kazakh Scientific Research Institute of Maral Husbandry
Heze Academy of Agricultural Sciences
Department of Bioinformatics
School of Medicine
Department of Chemistry
Department of Biochemistry
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