Modulation of insulin secretion and lipid profiles through glutamate dehydrogenase activators in diabetic rabbits
Nauryzbaevish A.S. Tatarinova G. Berikzhan O. Kunakbayev A. Tashenova G. Kapalbaevna A.G. Susarovna K.M. Sholpan S.
December 2023University of Guilan
Caspian Journal of Environmental Sciences
2023#21Issue 51229 - 1237 pp.
Diabetes mellitus is a prevalent metabolic disorder characterized by impaired insulin secretion and aberrant lipid metabolism. Targeting glutamate dehydrogenase (GDH) activators has emerged as a potential therapeutic strategy in managing diabetes. This study aims to investigate the effects of GDH activators on insulin secretion and lipid profiles in diabetic rabbits. Utilizing Streptozotocin (STZ) to induce diabetes in male New Zealand White rabbits, the impacts of three different GDH activators—Metformin, Epigallocatechin Gallate (EGCG), and Leucine— were examined. The subjects were categorized into five groups, including a diabetic control, a sham group, and three treatment groups administered with Metformin (5 mg kg-1), EGCG (15 mg kg-1), and Leucine (15 mg kg-1), respectively. The study reveals significant modulations in insulin and lipid profiles due to these treatments. In the Metformin-treated group, blood glucose levels significantly decreased during the second (p < 0.001) and third (p<0.01) weeks. The EGCG group exhibited a significant increase in insulin levels (p < 0.001), but no notable change in blood glucose. Conversely, the Leucine group showed an increase in triglyceride levels (p < 0.05) and a significant decrease in blood glucose levels (p < 0.01). Additionally, Metformin led to a substantial reduction in triglycerides (p < 0.001), while EGCG and Leucine were effective in lowering LDL levels (p < 0.01). Cholesterol and HDL levels remained relatively unchanged across all groups. These findings suggest that GDH activators, i.e., Metformin, EGCG, and Leucine, significantly impact insulin secretion and lipid metabolism, offering novel insights into diabetes management. This study not only demonstrates the therapeutic potential of these agents, but also emphasizes the importance of GDH pathways in diabetes research, providing a foundation for future investigations into metabolic regulation and treatment.
Amino acids , Diabetes , Enzymes , Hormones
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Institute of Genetics and Physiology CS MSHE RK, Almaty, Kazakhstan
Institute of Natural Sciences and Geography, Abai Kazakh National pedagogical university, 13, Dostyk Av., Almaty, 050010, Kazakhstan
Faculty of Natural Sciences, Zhetysu University named after I. Zhansugurov, Kazakhstan
Department of Anatomy with Physiology Courses, Kazakh-Russian Medical University, 13, Torekulova St., Almaty, 050004, Kazakhstan
Abai Kazakh National Pedagogical University named after Abai, Department of Biology, 050010, Kazakhstan
Al-Farabi Kazakh National University, Almaty, Kazakhstan
Institute of Natural Sciences and Geography of the Kazakh National Pedagogical University named after Abai, Almaty, Kazakhstan
Institute of Genetics and Physiology CS MSHE RK
Institute of Natural Sciences and Geography
Faculty of Natural Sciences
Department of Anatomy with Physiology Courses
Abai Kazakh National Pedagogical University named after Abai
Al-Farabi Kazakh National University
Institute of Natural Sciences and Geography of the Kazakh National Pedagogical University named after Abai
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