The Role of D-Serine and D-Aspartate in the Pathogenesis and Therapy of Treatment-Resistant Schizophrenia
Nasyrova R.F. Khasanova A.K. Altynbekov K.S. Asadullin A.R. Markina E.A. Gayduk A.J. Shipulin G.A. Petrova M.M. Shnayder N.A.
December 2022MDPI
Nutrients
2022#14Issue 23
Schizophrenia (Sch) is a severe and widespread mental disorder. Antipsychotics (APs) of the first and new generations as the first-line treatment of Sch are not effective in about a third of cases and are also unable to treat negative symptoms and cognitive deficits of schizophrenics. This explains the search for new therapeutic strategies for a disease-modifying therapy for treatment-resistant Sch (TRS). Biological compounds are of great interest to researchers and clinicians, among which D-Serine (D-Ser) and D-Aspartate (D-Asp) are among the promising ones. The Sch glutamate theory suggests that neurotransmission dysfunction caused by glutamate N-methyl-D-aspartate receptors (NMDARs) may represent a primary deficiency in this mental disorder and play an important role in the development of TRS. D-Ser and D-Asp are direct NMDAR agonists and may be involved in modulating the functional activity of dopaminergic neurons. This narrative review demonstrates both the biological role of D-Ser and D-Asp in the normal functioning of the central nervous system (CNS) and in the pathogenesis of Sch and TRS. Particular attention is paid to D-Ser and D-Asp as promising components of a nutritive disease-modifying therapy for TRS.
D-aspartate , D-serine , disease-modifying therapy , treatment-resistant schizophrenia
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Institute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, Saint Petersburg, 192019, Russian Federation
Department of Psychiatry, Russian Medical Academy for Continual Professional Education, Moscow, 125993, Russian Federation
International Centre for Education and Research in Neuropsychiatry, Samara State Medical University, Samara, 443016, Russian Federation
Republican Scientific and Practical Center of Mental Health, Almaty, 050022, Kazakhstan
Department of Psychiatry and Narcology, S.D. Asfendiarov Kazakh National Medical University, Almaty, 050022, Kazakhstan
Department of Psychiatry and Addiction, The Bashkir State Medical University, Ufa, 450008, Russian Federation
Centre for Strategic Planning and Management of Biomedical Health Risks Management, Moscow, 119121, Russian Federation
Shared Core Facilities “Molecular and Cell Technologies”, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russian Federation
Institute of Personalized Psychiatry and Neurology
Department of Psychiatry
International Centre for Education and Research in Neuropsychiatry
Republican Scientific and Practical Center of Mental Health
Department of Psychiatry and Narcology
Department of Psychiatry and Addiction
Centre for Strategic Planning and Management of Biomedical Health Risks Management
Shared Core Facilities “Molecular and Cell Technologies”
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