Single-Nucleotide Polymorphisms as Biomarkers of Antipsychotic-Induced Akathisia: Systematic Review

Nasyrova R.F. Vaiman E.E. Repkina V.V. Khasanova A.K. Asadullin A.R. Shipulin G.A. Altynbekov K.S. Al-Zamil M. Petrova M.M. Shnayder N.A.
March 2023 Multidisciplinary Digital Publishing Institute (MDPI)

Genes
2023 #14 Issue 3

Antipsychotic-induced akathisia (AIA) is a movement disorder characterized by a subjective feeling of inner restlessness or nervousness with an irresistible urge to move, resulting in repetitive movements of the limbs and torso, while taking antipsychotics (APs). In recent years, there have been some associative genetic studies of the predisposition to the development of AIA. Objective: The goal of our study was to review the results of associative genetic and genome-wide studies and to systematize and update the knowledge on the genetic predictors of AIA in patients with schizophrenia (Sch). Methods: We searched full-text publications in PubMed, Web of Science, Springer, Google Scholar, and e-Library databases from 1977 to 2022. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) quality scale was used for the critical selection of the studies. Results: We identified 37 articles, of which 3 were included in the review. Thus, the C allele of rs1800498 (59414 C>T) and the A allele of rs1800497 (17316 G>A) (TaqIA) from the DRD2 gene as well as the TT genotype rs13212041 (77461407 C>T) from the HTR1B gene were found to be associated with AIA. Conclusions: Uncovering the genetic biomarkers of AIA may provide a key to developing a strategy for the personalized prevention and treatment of this adverse neurological drug reaction of APs in patients with Sch in real clinical practice.

adverse drug reaction , antipsychotic-induced akathisia , antipsychotics , association , extrapyramidal disorder , gene , genetic biomarker , pharmacogenetics , single nucleotide variant , variation

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Institute of Personalized Psychiatry and Neurology, V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Saint Petersburg, 192019, Russian Federation
Department of Psychiatry, Russian Medical Academy for Continual Professional Education, Moscow, 125993, Russian Federation
Department of Psychiatry and Addiction, Bashkir State Medical University, Ufa, 450008, Russian Federation
Postgenome Technologies Center, Center for Strategic Planning of FMBA of Russia, Moscow, 119121, Russian Federation
Republican Scientific and Practical Center of Mental Health, Almaty, 050022, Kazakhstan
Department of Psychiatry and Narcology, S.D. Asfendiarov Kazakh National Medical University, Almaty, 050022, Kazakhstan
Department of Physiotherapy, Peoples’ Friendship University of Russia, Moscow, 117198, Russian Federation
Shared Core Facilities “Molecular and Cell Technologies”, V.F. Voino-Yasenetsky Krasnoyarsk State, Medical University, Krasnoyarsk, 660022, Russian Federation

Institute of Personalized Psychiatry and Neurology
Department of Psychiatry
Department of Psychiatry and Addiction
Postgenome Technologies Center
Republican Scientific and Practical Center of Mental Health
Department of Psychiatry and Narcology
Department of Physiotherapy
Shared Core Facilities “Molecular and Cell Technologies”

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