Updated aspects of alpha-Solanine as a potential anticancer agent: Mechanistic insights and future directions
Nandi S. Sikder R. Nag A. Khatua S. Sen S. Chakraborty N. Naskar A. Zhakipbekov K. Acharya K. Habtemariam S. Arslan Ateşşahin D. Goloshvili T. Ahmed Aldahish A. Sharifi-Rad J. Calina D.
October 2024John Wiley and Sons Inc
Food Science and Nutrition
2024#12Issue 107088 - 7107 pp.
Cancer remains a critical global health challenge, with limited progress in reducing mortality despite advancements in diagnosis and treatment. The growing resistance of tumors to existing chemotherapy exacerbates this burden. In response, the search for new anticancer compounds from plants has intensified, given their historical success in yielding effective treatments. This review focuses on α-solanine, a glycoalkaloid primarily derived from potato tubers and nightshade family plants, recognized for its diverse biological activities, including anti-allergic, antipyretic, anti-inflammatory, anti-diabetic, and antibiotic properties. Recently, α-solanine has gained attention as a potential anticancer agent. Utilizing resources like PubMed/MedLine, ScienceDirect, Web of Science, Scopus, the American Chemical Society, Google Scholar, Springer Link, Wiley, and various commercial websites, this review consolidates two decades of research on α-solanines anticancer effects and mechanisms against nine different cancers, highlighting its role in modulating various signaling pathways. It also discusses α-solanines potential as a lead compound in cancer therapy. The abundant availability of potato peel, often discarded as waste or sold cheaply, is suggested as a sustainable source for large-scale α-solanine extraction. The study concludes that α-solanine holds promise as a standalone or adjunctive cancer treatment. However, further research is necessary to optimize this lead compound and mitigate its toxicity through various strategies.
anticancer mechanisms , apoptosis , glycoalkaloids , Solanaceae , α-Solanine
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Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, India
Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bangalore, India
Department of Botany, Faculty of Science, University of Allahabad, Uttar Pradesh, Prayagraj, India
Department of Botany, Fakir Chand College, Kolkata, India
Department of Botany, Scottish Church College, Kolkata, India
Department of Organization and Management and Economics of Pharmacy and Clinical Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Pharmacognosy Research & Herbal Analysis Services UK, Kent, United Kingdom
Department of Plant and Animal Production, Baskil Vocational School, Fırat University, Elazıg, Turkey
Department of Plant Physiology and Genetic Resources, Institute of Botany, Ilia State University, Tbilisi, Georgia
Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
Department of Biomedical Sciences, College of Medicine, Korea University, Seoul, South Korea
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Molecular and Applied Mycology and Plant Pathology Laboratory
Department of Life Sciences
Department of Botany
Department of Botany
Department of Botany
Department of Organization and Management and Economics of Pharmacy and Clinical Pharmacy
Pharmacognosy Research & Herbal Analysis Services UK
Department of Plant and Animal Production
Department of Plant Physiology and Genetic Resources
Department of Pharmacology
Department of Biomedical Sciences
Department of Clinical Pharmacy
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