Synthesis of New Taurine Derivatives by Reaction of 2-Aryl-1-(vinylsulfonyl)pyrrolidines with Optically Pure Amines
Nakypova S.M. Smolobochkin A.V. Gazizov A.S. Gerasimova D.P. Akylbekov N.I. Burilov A.R.
July 2025Pleiades Publishing
Russian Journal of General Chemistry
2025#95Issue 71765 - 1770 pp.
Abstract: A method was proposed for the synthesis hybrid molecules combining fragments of pyrrolidine, taurine, amino acids or 1-phenylethan-1-amine. The method is based on the reaction of 2-aryl-1-(vinylsulfonyl)pyrrolidines with amino acids or their esters by boiling in acetonitrile in the presence of triethylamine for 2 days. The structure of the obtained compounds was proven by 1H, 13C NMR and single crystal X-ray diffraction analysis methods.
amino acids , aza-Michael reaction , pyrrolidine , taurine
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Al Farabi Kazakh National University, Almaty, 050038, Kazakhstan
Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”, Kazan, 420088, Russian Federation
Korkyt Ata Kyzylorda University, Kyzylorda, 120014, Kazakhstan
Al Farabi Kazakh National University
Arbuzov Institute of Organic and Physical Chemistry
Korkyt Ata Kyzylorda University
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