Synthesis, characterization and antibacterial application of copolymers based on n,n-dimethyl acrylamide and acrylic acid

Nakan U. Bieerkehazhi S. Tolkyn B. Mun G.A. Assanov M. Nursultanov M.E. Rakhmetullayeva R.K. Toshtay K. Negim E.-S. Ydyrys A.
October-2 2021 MDPI

Materials
2021 #14 Issue 20

Hydrogel copolymers based on N,N-dimethyl acrylamide (DMA) and acrylic acid (AAc) were synthesized using a solution polymerization technique with different monomer ratios and ammonium persulfate as an initiator. This paper investigates the thermal stability, physical and chemical properties of the hydrogel copolymer. Testing includes Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and elemental analysis (CHNS). The copolymer composition was determined by elemental analysis, and the reactivity ratios of monomers were calculated through linearization methods such as Fineman– Ross (FR), inverted Fineman–Ross (IFR), Kelen–Tudos (KT) and Mayo–Lewis (ML). Good agreement was observed between the results of all four methods. The ratio of r1 and r2 were 0.38 (r1) and 1.45 (r2) (FR), 0.38 (r1) and 1.46 (r2) (IFR), 0.38 (r1) and 1.43 (r2) (KT), and 0.38 (r1) and 1.45 (r2) (ML). Hydrogel copolymers exhibited good thermal stability, and SEM showed three-dimensional porous structures. Antibiotic-free and antibiotic-loaded hydrogels demonstrated antimicrobial properties against both Gram-positive and Gram-negative bacteria. As the ratio of DMA in hydrogel copolymer increased, the activity of copolymer against bacteria enhanced. The results indicated that these hydrogels have the potential to be used as antibacterial materials.

Acrylic acid , Antibacterial activity , Fineman–Ross , Inverted Fineman–Ross , Kelen–Tudos , N,N-dimethyl acrylamide , Reactivity ratios

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Institute of Geology and Oil & Gas Business, Satbayev University, Almaty, 050013, Kazakhstan
Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, M5S 1A1, ON, Canada
A.B. Bekturov Institute of Chemical Sciences, Street Ualihanov106, Almaty, 050010, Kazakhstan
Al-Farabi Kazakh National University, Almaty, 050012, Kazakhstan
Laboratory of Advanced Materials and Technology, Kazakh-British Technical University, 59 Tole bi St., Almaty, 050000, Kazakhstan
Biomedical Research Centre, Al-Farabi Kazakh National University, al-Farabi 71, Almaty, 050040, Kazakhstan

Institute of Geology and Oil & Gas Business
Ross Tilley Burn Centre
A.B. Bekturov Institute of Chemical Sciences
Al-Farabi Kazakh National University
Laboratory of Advanced Materials and Technology
Biomedical Research Centre

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