Nanotechnology-enhanced delivery of α- and β-mangostins for cancer therapy: mechanistic insights and clinical perspectives
Nahar L. Charoensup R. Kaliyeva K. Wang D. Habibi E. Duangyod T. Khuniad C. Choeibuakaew W. Sermkaew N. Songnaka N. Ren J. Wang X. Nath R. D. Talukdar A. Khalifa S.A.M. El-Seedi H.R. Guo M. Sarker S.D.
2025Springer Science and Business Media B.V.
Phytochemistry Reviews
2025
Cancer remains a major global health burden, demanding the development of more effective and less toxic therapies. α- and β-Mangostins are natural xanthones derived from Garcinia mangostana L. (mangosteen fruit) of the family Clusiaceae. They have demonstrated strong anticancer effects, including inhibition of cancer cell proliferation, induction of apoptosis, and anti-inflammatory properties. However, their clinical application is limited due to poor solubility and low bioavailability. Nanotechnology offers a promising solution to these challenges by improving the solubility, targeted delivery, and therapeutic potential of α- and β-mangostins. Recent advancements in nanotechnology-assisted drug delivery systems, including polymeric nanoparticles, lipid-based nanocarriers, and other nanoformulations, have significantly enhanced the bioavailability and controlled release of these compounds, thereby minimizing potential side effects. Furthermore, nanotechnology enables the co-delivery of multiple therapeutic agents, creating avenues for more effective combination therapies. In addition to reviewing the role of nanotechnology in delivering α- and β-mangostins for cancer therapy and future clinical applications, this article provides further mechanistic insights using in silico studies. Molecular docking studies have demonstrated how α- and β-mangostins interact with key cancer-related proteins, enhancing their anticancer efficacy. Ongoing research could lead to safer, more effective treatments that maximize the anticancer potential of these compounds across different cancer types.
Cancer therapy , Controlled release , Drug delivery , Mangostins , Molecular docking , Nanotechnology
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Laboratory of Growth Regulators, Palacký University and Institute of Experimental Botany, The Czech Academy of Sciences, Šlechtitelů 27, Olomouc, 78371, Czech Republic
School of Integrative Medicine, Mae Fah Luang University, Chiangrai, 57100, Thailand
Medicinal Plants Innovation Center of Mae Fah, Luang University, Chiangrai, 57100, Thailand
Deapartment of Chemistry and Mathematics, Al-Farabi Kazakh National University, 71 Al-Farabi Ave., Almaty, 050040, Kazakhstan
International Joint Laboratory of Medicinal Food Development and Health Products Creation, Biological Engineering Technology Innovation Center of Shandong Province, Heze Branch of Qilu University of Technology (Shandong Academy of Sciences), Heze, China
Department of Pharmacognosy, Medicinal Plants Research Centre, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, United Kingdom
Department of Thai Traditional Medicine, Faculty of Health and Sports Science, Thaksin University, Phatthalung, 93210, Thailand
Faculty of Health and Sports Science, Thaksin University, Phatthalung, 93210, Thailand
School of Pharmacy, Walailak University, Nakhon Si Thammarat, Thasala, 80160, Thailand
Drug and Cosmetics Excellence Center, Walailak University, Nakhon Si Thammarat, Thasala, 80160, Thailand
Institute of Automation, Qilu University of Technology (Shandong Academy of Sciences), Jinan City, China
Department of Biotechnology and Microbiology, School of Natural Sciences, Techno India University, Tripura (TIUT), Agartala, India
Department of Life Science and Bioinformatics, Assam University, Assam, India
Neurology and Psychiatry Department, Capio Saint Göran’s Hospital, Sankt Göransplan 1, Stockholm, 112 19, Sweden
Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, 42351, Saudi Arabia
Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, China
Laboratory of Growth Regulators
School of Integrative Medicine
Medicinal Plants Innovation Center of Mae Fah
Deapartment of Chemistry and Mathematics
International Joint Laboratory of Medicinal Food Development and Health Products Creation
Department of Pharmacognosy
Centre for Natural Products Discovery
Department of Thai Traditional Medicine
Faculty of Health and Sports Science
School of Pharmacy
Drug and Cosmetics Excellence Center
Institute of Automation
Department of Biotechnology and Microbiology
Department of Life Science and Bioinformatics
Neurology and Psychiatry Department
Department of Chemistry
Laboratory of Advanced Theranostic Materials and Technology
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