Hormonal Therapies before in vitro fertilization in women with endometriosis: The Minotaurs Labyrinth and the Ariadnes Thread
Naem A. Krentel H. Moawad G. Naem J. Venezia R. Etrusco A. Terzic S. Laganà A.S.
July 2024Bailliere Tindall Ltd
Best Practice and Research: Clinical Obstetrics and Gynaecology
2024#95
Endometriosis-related infertility is one of the most debated topics in reproductive medicine. In recent years, prolonged pre-cycle hormonal regimens gained attention as a mean of improving the assisted reproduction technologies (ART) success rates in endometriosis patients. GnRH agonists, dienogest, medroxyprogesterone acetate, and aromatase inhibitors are the most studied medications. Conflicting results and a high risk of bias exist in almost all of the conducted studies in the field. However, current evidence suggests that pre-cycle treatment with GnRH agonists may be beneficial for patients with stage III/IV endometriosis. Dienogest and medroxyprogesterone acetate-based progestin-primed ovarian stimulation protocol was shown to be comparable to the prolonged GnRH agonists protocol. Finally, aromatase inhibitors seem to be of limited benefit to the assisted reproductive outcomes of endometriosis patients. Although it is challenging to draw any clinical conclusions, pre-cycle hormonal treatments seem to be best indicated in endometriosis patients who had previously failed ART treatment.
Aromatase inhibitors , Dienogest , Endometriosis , GnRH agonists , In vitro fertilization , Infertility
Text of the article Перейти на текст статьи
Department of Obstetrics, Gynecology, Gynecologic Oncology and Senology, Bethesda Hospital Duisburg, Duisburg, 47053, Germany
Faculty of Mathematics and Computer Science, University of Bremen, Bremen, 28359, Germany
Department of Obstetrics and Gynecology, George Washington University, Washington, 20037, DC, United States
The Center for Endometriosis and Advanced Pelvic Surgery, Washington, 22101, DC, United States
Faculty of Medicine of Damascus University, Damascus, Syrian Arab Republic
Unit of Obstetrics and Gynecology, “Paolo Giaccone” Hospital, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, 90127, Italy
Department of Medicine, School of Medicine, Nazarbayev University, Zhanybek-Kerey Khans Street 5/1, Astana, 010000, Kazakhstan
Department of Obstetrics
Faculty of Mathematics and Computer Science
Department of Obstetrics and Gynecology
The Center for Endometriosis and Advanced Pelvic Surgery
Faculty of Medicine of Damascus University
Unit of Obstetrics and Gynecology
Department of Medicine
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026