Photophysical properties of protoporphyrin IX, pyropheophorbide-a and photofrin® in different conditions
Myrzakhmetov B. Arnoux P. Mordon S. Acherar S. Tsoy I. Frochot C.
February 2021MDPI AG
Pharmaceuticals
2021#14Issue 21 - 21 pp.
Photodynamic therapy (PDT) is an innovative treatment of malignant or diseased tissues. The effectiveness of PDT depends on light dosimetry, oxygen availability, and properties of the photosensitizer (PS). Depending on the medium, photophysical properties of the PS can change leading to increase or decrease in fluorescence emission and formation of reactive oxygen species (ROS) especially singlet oxygen (1O2). In this study, the influence of solvent polarity, viscosity, concentration, temperature, and pH medium on the photophysical properties of protoporphyrin IX, pyropheophorbide-a, and Photofrin® were investigated by UV-visible absorption, fluorescence emission, singlet oxygen emission, and time-resolved fluorescence spectroscopies.
Absorption , Fluorescence , Photodynamic therapy , Photofrin® , Protoporphyrin IX , Pyropheophorbide-a , Singlet oxygen
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LRGP UMR 7274, CNRS, University of Lorraine, Nancy, 54000, France
Department of Chemistry and Chemical Technology, M.Kh. Dulaty Taraz Regional University, Taraz, 080012, Kazakhstan
ONCO-THAI U1189, INSERM, CHU Lille, University of Lille, Lille, 59000, France
LCPM UMR 7375, CNRS, University of Lorraine, Nancy, 54000, France
LRGP UMR 7274
Department of Chemistry and Chemical Technology
ONCO-THAI U1189
LCPM UMR 7375
10 лет помогаем публиковать статьи Международный издатель
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