Synergistic Effects of Carbon Nanotubes with Methotrexate for Osteosarcoma: A Review

Myrzahanovna S.A. Habeeb N.Z. Al-Anbari H.H.A. Mohammed B.A.R. Radhi F. Bokhoor S.N. Yasin H.A. Khalaf R.M. Nurlanovich K.Y.
April 2025 University of Kashan

Journal of Nanostructures
2025 #15 Issue 2 712 - 719 pp.

Osteosarcoma, a highly aggressive primary bone cancer, poses significant therapeutic challenges, particularly due to multidrug resistance and limited efficacy of conventional chemotherapy. Methotrexate (MTX), a widely used antineoplastic agent, suffers from poor bioavailability and systemic toxicity, necessitating the development of advanced drug delivery approaches. In this study, carbon nanotubes (CNTs) are explored as nanocarriers to enhance MTX delivery, aiming to improve therapeutic outcomes. CNTs offer unique physicochemical properties, including high surface area, functionalization potential, and efficient cellular uptake, which can facilitate targeted drug transport and sustained release. The synergistic interaction between CNTs and MTX enhances drug bioavailability, minimizes off-target effects, and improves cytotoxic efficacy against osteosarcoma cells. Experimental findings suggest that CNT-based MTX delivery can overcome resistance mechanisms and significantly improve therapeutic precision. This paper reviewed the current advancements in CNT-mediated drug delivery systems for osteosarcoma, summarizing key experimental findings their implications in overcoming therapeutic challenges.

Carbon Nanotubes , Drug delivery , Methotrexate , Osteosarcoma , Synergistic Effects

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Department of Chemistry and Biology, Peoples’ Friendship University named after Academician A. Kuatbekov, Shymkent, Kazakhstan
Department of physics, College of Education for Pure Sciences, University Of Anbar, Iraq
College of Pharmacy, Ahl Al Bayt University, Kerbala, Iraq
Al-Hadi University College, Baghdad, Iraq
Department of Dentistry, Al-Manara College For Medical Sciences, Maysan, Iraq
College of Health and Medical Technologies, National University of Science and Technology, Dhi Qar, Iraq
Department of Medical Laboratories Technology, Al-Nisour University College, Baghdad, Iraq
Mazaya University College, Iraq
O. Zhanibekov South Kazakhstan Pedagogical University, Shymken, Kazakhstan

Department of Chemistry and Biology
Department of physics
College of Pharmacy
Al-Hadi University College
Department of Dentistry
College of Health and Medical Technologies
Department of Medical Laboratories Technology
Mazaya University College
O. Zhanibekov South Kazakhstan Pedagogical University

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