The role of collagen triple helix repeat-containing 1 protein (Cthrc1) in rheumatoid arthritis
Myngbay A. Manarbek L. Ludbrook S. Kunz J.
1 March 2021MDPI AG
International Journal of Molecular Sciences
2021#22Issue 51 - 16 pp.
Rheumatoid arthritis (RA) is a chronic autoimmune disease causing inflammation of joints, cartilage destruction and bone erosion. Biomarkers and new drug targets are actively sought and progressed to improve available options for patient treatment. The Collagen Triple Helix Repeat Containing 1 protein (CTHRC1) may have an important role as a biomarker for rheumatoid arthritis, as CTHRC1 protein concentration is significantly elevated in the peripheral blood of rheumatoid arthritis patients compared to osteoarthritis (OA) patients and healthy individuals. CTHRC1 is a secreted glycoprotein that promotes cell migration and has been implicated in arterial tissuerepair processes. Furthermore, high CTHRC1 expression is observed in many types of cancer and is associated with cancer metastasis to the bone and poor patient prognosis. However, the function of CTHRC1 in RA is still largely undefined. The aim of this review is to summarize recent findings on the role of CTHRC1 as a potential biomarker and pathogenic driver of RA progression. We will discuss emerging evidence linking CTHRC1 to the pathogenic behavior of fibroblast-like synoviocytes and to cartilage and bone erosion through modulation of the balance between bone resorption and repair.
Biomarker , Bone erosion , Cartilage destruction , Collagen triple helix repeat containing 1 , CTHRC1 , Fibroblast-like synoviocytes , Rheumatoid arthritis , Wnt signaling
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Science Engineering and Technology, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan
Department of Biology, School of Sciences and Humanities, Nazarbayev University, Nur Sultan, 010000, Kazakhstan
GlaxoSmithKline Research & Development, Stevenage, SG1 2NY, United Kingdom
Science Engineering and Technology
Department of Biology
GlaxoSmithKline Research & Development
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