In vitro evaluation of electrochemically bioactivated Ti6Al4V 3D porous scaffolds

Myakinin A. Turlybekuly A. Pogrebnjak A. Mirek A. Bechelany M. Liubchak I. Oleshko O. Husak Y. Korniienko V. Leśniak-Ziółkowska K. Dogadkin D. Banasiuk R. Moskalenko R. Pogorielov M. Simka W.
February 2021 Elsevier Ltd

Materials Science and Engineering C
2021 #121

Triply periodic minimal surfaces (TPMS) are known for their advanced mechanical properties and are wrinkle-free with a smooth local topology. These surfaces provide suitable conditions for cell attachment and proliferation. In this study, the in vitro osteoinductive and antibacterial properties of scaffolds with different minimal pore diameters and architectures were investigated. For the first time, scaffolds with TPMS architecture were treated electrochemically by plasma electrolytic oxidation (PEO) with and without silver nanoparticles (AgNPs) to enhance the surface bioactivity. It was found that the scaffold architecture had a greater impact on the osteoblast cell activity than the pore size. Through control of the architecture type, the collagen production by osteoblast cells increased by 18.9% and by 43.0% in the case of additional surface PEO bioactivation. The manufactured scaffolds demonstrated an extremely low quasi-elastic modulus (comparable with trabecular and cortical bone), which was 5–10 times lower than that of bulk titanium (6.4–11.4 GPa vs 100–105 GPa). The AgNPs provided antibacterial properties against both gram-positive and gram-negative bacteria and had no significant impact on the osteoblast cell growth. Complex experimental results show the in vitro effectiveness of the PEO-modified TPMS architecture, which could positively impact the clinical applications of porous bioactive implants.

3D printed Ti6Al4V scaffolds , Ag nanoparticles , Antibacterial coating , Plasma electrolytic oxidation

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D. Serikbayev East Kazakhstan State Technical University, Oskemen, F02K6B2, Kazakhstan
Nazarbayev University, Nur-Sultan, Z05H0P9, Kazakhstan
Sumy State University, Medical Institute, Sumy, 40018, Ukraine
al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Institut Européen des Membranes, IEM, UMR-5635, University Montpellier, CNRS, ENSCM, Montpellier CEDEX 5, 34095, France
Nalecz Institute of Biocybernetics and Biomedical Engineering PAS, Warsaw, 02-109, Poland
Silesian University of Technology, Faculty of Chemistry, Gliwice, 44-100, Poland
NanoWave, Warsaw, 02-676, Poland
Institute of Biotechnology and Molecular Medicine, Gdansk, 80-172, Poland
NanoPrime, Dębica, 32-900, Poland

D. Serikbayev East Kazakhstan State Technical University
Nazarbayev University
Sumy State University
al-Farabi Kazakh National University
Institut Européen des Membranes
Nalecz Institute of Biocybernetics and Biomedical Engineering PAS
Silesian University of Technology
NanoWave
Institute of Biotechnology and Molecular Medicine
NanoPrime

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