Gut Microbiome and Cytokine Profiles in Post-COVID Syndrome
Mussabay K. Kozhakhmetov S. Dusmagambetov M. Mynzhanova A. Nurgaziyev M. Jarmukhanov Z. Vinogradova E. Dusmagambetova A. Daulbaeva A. Chulenbayeva L. Tauekelova A. Bekbossynova M. Kushugulova A.
May 2024Multidisciplinary Digital Publishing Institute (MDPI)
Viruses
2024#16Issue 5
Recent studies highlight the crucial role of the gut microbiome in post-infectious complications, especially in patients recovering from severe COVID-19. Our research aimed to explore the connection between gut microbiome changes and the cytokine profile of patients with post-COVID syndrome. Using 16S rRNA amplicon sequencing, we analyzed the composition of the gut microbiome in 60 COVID-19 patients over the course of one year. We also measured the levels of serum cytokines and chemokines using the Milliplex system. Our results showed that severe SARS-CoV-2 infection cases, especially those complicated by pneumonia, induce a pro-inflammatory microbial milieu with heightened presence of Bacteroides, Faecalibacterium, and Prevotella_9. Furthermore, we found that post-COVID syndrome is characterized by a cross-correlation of various cytokines and chemokines MDC, IL-1b, Fractalkine, TNFa, FGF-2, EGF, IL-1RA, IFN-a2, IL-10, sCD40L, IL-8, Eotaxin, IL-12p40, and MIP-1b as well as a shift in the gut microbiome towards a pro-inflammatory profile. At the functional level, our analysis revealed associations with post-COVID-19 in homolactic fermentation, pentose phosphate, NAD salvage, and flavin biosynthesis. These findings highlight the intricate interplay between the gut microbiota, their metabolites, and systemic cytokines in shaping post-COVID symptoms. Unraveling the gut microbiome’s role in post-infectious complications opens avenues for new treatments for those patients with prolonged symptoms.
cytokine storm , cytokines , gut microbiome , Post-COVID , SARS-CoV-2
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Department of Microbiology and Virology Named after Sh.I.Sarbasova, Astana Medical University, Astana, 010000, Kazakhstan
Laboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, 010000, Kazakhstan
Department of Pediatric Infectious Diseases, Astana Medical University, Astana, 010000, Kazakhstan
National Research Cardiac Surgery Center, Astana, 010000, Kazakhstan
Department of Microbiology and Virology Named after Sh.I.Sarbasova
Laboratory of Microbiome
Department of Pediatric Infectious Diseases
National Research Cardiac Surgery Center
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