Association of β2 microglobulin level and glomerular filtration rate in patients with acute leukemia after hematopoietic stem cell transplantation
Murzakhmetova A.O. Kamkhen V.B. Ainabay A.M. Meiramova A.M. Kemaykin V.M. Ainabekova B.A.
2023Page Press Publications
Italian Journal of Medicine
2023#17Issue 1
Hematopoietic stem cell transplantation is a life-saving therapy in patients suffering from acute leukemia. However, kidney complications developed after performing hematopoietic stem cell transplantation can affect the course and prognosis of the disease in patients with acute leukemia. This study is aimed at assessing the functional status of the kidneys in patients with acute leukemia who have undergone hematopoietic stem cell transplantation. The study has observed a group of patients with acute lymphoblastic leukemia and acute myeloid leukemia who have undergone hematopoietic stem cell transplantation. It has been discovered that β2 microglobulin is a sensitive method of analyzing renal function, with the β2 microglobulin threshold urine level not exceeding 0.3 mg/L. The complex diagnostics of kidney function in hematopoietic stem cell transplantation recipients has given the opportunity to identify the relationship between increased β2 microglobulin levels and decreased glomerular filtration rate. It has been determined that β2 microglobulin is a biomarker of renal disorders. The obtained data have showed that β2 microglobulin can be used as a diagnostic marker of reduced kidney function.
acute leukemia , biomarkers of renal function , glomerular filtration rate , Hematopoietic stem cell transplantation , β2 microglobulin
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Department of Internal Medicine with the Course of Gastroenterology, Endocrinology and Pulmonology, NJSC Astana Medical University, Astana, Kazakhstan
Al-Farabi Kazakh National University, Almaty, Kazakhstan
National Research Oncology Center, Astana, Kazakhstan
Department of Internal Medicine with the Course of Gastroenterology
Al-Farabi Kazakh National University
National Research Oncology Center
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