CLINICAL AND LABORATORY PARALLELS OF CYSTATIN C AND LIPID METABOLISM PARAMETERS IN PERSONS WITH HIGH CARDIOVASCULAR RISK

Murkamilov I.T. Fomin V.V. Murkamilova Zh.A. Sabirov I.S. Sabirova A.I. Umurzakov Sh.E. Yusupov F.A. Yusupova G.S. Gassanov K.A.
2023 Klinichescheskaya Laboratornaya Diagnostika

Klinichescheskaya Laboratornaya Diagnostika
2023 #68 Issue 1 23 - 31 pp.

Purpose of the study: to study the relationship between cystatin C concentration and lipid metabolism parameters in individuals with high cardiovascular risk. A comprehensive clinical and laboratory analysis was carried out in 215 patients (mean age 50.0 ± 13.7 years) with a high cardiovascular risk, of which 91 were men and 124 were women. The participants of the study were divided into two groups: the 1st group (n=96, mean age 53.5±15.3 years) consisted of individuals with impaired lipid metabolism, i.e. dyslipidemia (DLD), hypercholesterolemia (HCS) and hypertriglyceridemia (HTG); group 2 – 119 patients (mean age 46.7±10.8 years) without lipid metabolism disorders. At the same time, subgroups were identified from groups 1 and 2, taking into account gender differences: 1A – a subgroup of men (with and without lipid metabolism disorders) and 2B – a subgroup of women (with and without lipid metabolism disorders). In all examined patients, anthropometric data, hemodynamics and biochemical parameters of blood were evaluated. In patients with high cardiovascular risk, in the structure of lipid metabolism disorders, an increase in the concentration of low-density lipoprotein cholesterol (LDL-C) – 80.2%, HCH – 73.9%, HTG – 46.8% and a reduced level of high-density lipoprotein cholesterol density (HDL-C) – 20.8%. In men with impaired lipid metabolism, a reduced level of HDL-C (32.5%) is most often detected. Individuals with high cardiovascular risk and lipid disorders were characterized by older age, high body mass index (BMI), elevated levels of systolic and diastolic blood pressure (BP), cystatin C, reduced concentrations of Hb and magnesium in the blood, and decreased renal functions. Among the examined patients with high cardiovascular risk and the absence of lipid metabolism disorders, there was a significant increase in the level of systolic blood pressure and serum cystatin C, as well as a significantly reduced level of HDL-C and filtration function of the kidneys in men and a decrease in hemoglobin concentration in women. It was shown that there is a close relationship between the content of cystatin C (r=0.276; p=0.004) and the value of the glomerular filtration rate (GFR, r=-0.246; p=0.010) with the concentration of total cholesterol (TC). LDL-C concentration significantly correlated with cystatin C (r=0.269; p=0.005) and diastolic BP level, and also negatively correlated with GFR (r=-0.234; p=0.014). Elevated serum TG levels were positively associated with heart rate (HR) (r=0.250; p=0.009).

atherosclerosis , cardiovascular disease , cardiovascular risk , cystatin C , dyslipidemia , lipid spectrum , prevention , risk factor

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Kyrgyz State Medical Academy named after I.K. Akhunbaev, Bishkek, 720020, Kyrgyzstan
Kyrgyz Russian Slavic University, Bishkek, 720000, Kyrgyzstan
FSAEI HE First Moscow State Medical University named after I.M. Sechenov, Moscow, 119991, Russian Federation
Osh State University, Osh, 723500, Kyrgyzstan
South Kazakhstan Medical Academy, Shymkent, 160019, Kazakhstan

Kyrgyz State Medical Academy named after I.K. Akhunbaev
Kyrgyz Russian Slavic University
FSAEI HE First Moscow State Medical University named after I.M. Sechenov
Osh State University
South Kazakhstan Medical Academy

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