Chronic cerebral ischemia in therapeutic hospital patients

Murkamilov I.T. Aitbaev K.A. Murkamilova Z.A. Fomin V.V. Yusupov F.A. Kudaibergenova I.O. Maanaev T.I. Gassanov K.A.
2023 Media Sphera Publishing Group

Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova
2023 #123 Issue 3-2 50 - 57 pp.

Objective. To study the features of clinical and functional manifestations of the syndrome of chronic cerebral ischemia (CCI) in therapeutic patients. Material and methods. Patients (n=577) in therapeutic departments were selected by random sampling. Of these, 277 patients had verified CCI. Results. Patients with CCI, compared with the control group, were older (61.7±9.6 years and 43.3±12.2 years, p<0.05), had a significant increase in body mass index (28.5±5.1 and 26.9±5.7 kg/m², p<0.05), systolic level (140±20 and 127±17 mmHg, p<0.05) and diastolic blood pressure (87±10 and 82±11 mm Hg, p<0.05), platelet count in peripheral blood (278.0±70.7·10⁹/l and 259.1±80.8·10⁹/l, p<0.05), venous blood glucose (7.11±3.8 and 5.31±1.7 mmol/l, p<0.05), triglycerides (1.37 (1.01; 1.97) mmol/l and 1.34 (0.96; 1.96) mmol/l, p<0.05), uric acid (0.425±0.12 and 0.374±0.14 mmol/l, p<0.05), creatinine (82.7 (68.0; 114.0) µmol/l and 72.3 (61.8; 93.0) µmol/l, p<0.05) and cystatin C (1.24 (1.08;1.62) mg/l and 1.01 (0.87; 1.32) mg/l, p<0.05). Statistically significant decrease in the concentration of high-density lipoprotein cholesterol (1.0±0.28 mmol/l and 1.2±0.32 mmol/l, p<0.05), serum magnesium (0.90±0.15 and 0.94±0.13 mmol/l, p<0.05) and estimated GFR (57.9±24 and 72.6±26.8 ml/min, p<0.05) were characteristic of patients with CCI. Elevated levels of C-reactive protein and anemia were significantly more common in these patients. A close correlation was found between the concentrations of uric acid (r=0.786; p<0.001) and cystatin C (r=0.587; p<0.005) in blood serum and the thickness of the intima-media complex of the carotid arteries. Conclusion. In patients of a therapeutic hospital, CCI is associated with older age, weight gain, arterial hypertension, dyslipidemia, anemia, inflammation, hypomagnesemia, hyperuricemia, thickening of the intima-media complex of the carotid arteries, and a decrease in the functional state of the kidneys.

chronic cerebral ischemia , creatinine , cystatin C , glomerular filtration rate , kidney function , prevalence , therapeutic hospital , uric acid

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Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan
Yeltsin The First President of the Russian Federation Kyrgyz Russian Slavic University, Bishkek, Kyrgyzstan
Scientific and Research Institute of Molecular Biology and Medicine, Bishkek, Kyrgyzstan
Sechenov First Moscow State Medical University, Moscow, Russian Federation
Osh State University, Osh, Kyrgyzstan
National Hospital under the Ministry of Health of the Kyrgyz Republic, Bishkek, Kyrgyzstan
South Kazakhstan Medical Academy, Shymkent, Kazakhstan

Akhunbaev Kyrgyz State Medical Academy
Yeltsin The First President of the Russian Federation Kyrgyz Russian Slavic University
Scientific and Research Institute of Molecular Biology and Medicine
Sechenov First Moscow State Medical University
Osh State University
National Hospital under the Ministry of Health of the Kyrgyz Republic
South Kazakhstan Medical Academy

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