Mesoporous silica decorated with gold nanoparticles as a promising nanoprobe for effective CT X-ray attenuation and potential drug delivery
Mulikova T. Abduraimova A. Molkenova A. Em S. Duisenbayeva B. Han D.-W. Atabaev T.S.
April 2021Elsevier B.V.
Nano-Structures and Nano-Objects
2021#26
The design of multifunctional agents became a pivotal task for the development of personalized medicine. In this study, we investigated the potential applicability of mesoporous silica decorated with gold nanoparticles (MS-Au NPs) for effective X-ray attenuation in computed tomography (CT) and as a potential vehicle for drug delivery. The physicochemical properties and X-ray attenuation efficiency of prepared MS-Au NPs were systematically studied using a range of characterization techniques and clinical CT correspondingly. CT analysis revealed that prepared MS-Au NPs exhibit high X-ray attenuation efficiency ∼9.8 HU/mM (Hounsfield Units per mM of Au) as compared to other perspective metal-based nanoparticles reported in the literature. An improved X-ray attenuation efficiency can be attributed to the presence of a large amount of Au nanoparticles in a confined volume unit.
Au nanoparticles , Computed tomography , Drug delivery , Mesoporous silica , X-ray attenuation
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Department of Chemistry, Nazarbayev University, Nur-Sultan, Kazakhstan
Department of Biology, Nazarbayev University, Nur-Sultan, Kazakhstan
Department of Radiology, Green Clinic, Nur-Sultan, Kazakhstan
Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, South Korea
Department of Chemistry
Department of Biology
Department of Radiology
Department of Cogno-Mechatronics Engineering
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026