THE STUDY OF ANTIMICROBIAL AND ANALGESIC ACTIVITY OF CERTAIN CYTIZINE ALKALOID COMBINED DERIVATIVES

ИЗУЧЕНИЕ АНТИМИКРОБНОЙ И АНАЛЬГЕТИЧЕСКОЙ АКТИВНОСТИ НЕКОТОРЫХ КОМБИНИРОВАННЫХ ПРОИЗВОДНЫХ АЛКАЛОИДА ЦИТИЗИН
Mukusheva G.K. Seidakhmetova R.B. Zhassymbekova A.R. Nurkenov O.A. Nurmaganbetov Zh.S. Seilkhanov T.M. Tazhybay A.M. Mazhytov A.S.
2022 Altai State University

Khimiya Rastitelnogo Syrya
2022 Issue 4 256 - 267 pp.

The modern vegetable matter studies in the republic and abroad are devoted to a multi-faceted and comprehensive research of plant raw materials, including desorbing and structure of plant component chemical properties, the study of their biological activity, as well as the development of effective and environmentally friendly methods for соmprehensive mineral processing of plant raw materials. The 1,2,3-triazoles attraction is due to their reactivity versatility, as well as practical application of 1,2,3-triazole derivatives as medicines. Modification of natural compound molecules by introducing such a substituent is one of promising directions in the search for new biologically active compounds. According to the data obtained, the antimicrobial activity of sample (5) is higher than that of sample (3). Thus, sample (5) showed a moderate antibacterial activity against Escherichia coli, whereas sample (3) showed a weak antimicrobial activity against this test strain. The analysis of test results concerning the analgesic activity assessment showed that samples (5) and (3) can reduce the rats specific nociceptive responses severity when testing abdominal constriction. It is important to emphasize that when injecting a 1% acetic acid solution abdominally, all test animals developed “acetic writhings” (characteristic animal movements, including the abdominal muscles contraction, alternating with their relaxation, hind limbs stretching and back arching).

alkaloids , combined derivatives , cytisine , lupinine , pharmacological activity , quinine

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Karagandy University of the name of Academician E.A. Buketov, ul. Universitetskaya, 28, Karaganda, 100009, Kazakhstan
Institute of Organic Synthesis and Coal Chemistry, ul. Alikhanova, 1, Karaganda, 100012, Kazakhstan
Sh.Ualikhanov Kokshetau university, ul. Abaya, 76, Kokshetau, 020000, Kazakhstan

Karagandy University of the name of Academician E.A. Buketov
Institute of Organic Synthesis and Coal Chemistry
Sh.Ualikhanov Kokshetau university

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