Synthesis and structure of new modified derivatives based on the quinine molecule and their biological activity
Mukusheva G. Zhasymbekova A. Nurmaganbetov Z.
1 March 2023Sciendo
Polish Journal of Chemical Technology
2023#25Issue 128 - 34 pp.
The relevance of the subject matter is conditioned by the constantly growing need to meet human needs in the field of medicine, in particular, the search, study, and further introduction of new types of medicines into practical use. The purpose of this study is to investigate the synthesis of modified quinine alkaloid derivatives, and their structure, to identify the properties and biological activity of antimalarial drugs based on quinine molecules, and to structure the general data of these substances. The leading approach is the analysis of the synthesis of quinine derivatives, their chemical and physical properties, and their ability to exert a medicinal effect. The abstracting method allows structuring alkaloid derivatives and establishing a general relationship between the structural configuration of molecules and their impact on human health in a number of related derivatives. The study identifies the main antimalarial drugs based on quinine molecules, including a comparative analysis of their effectiveness and overall biological activity.
antimalarial drug , chloroquine , hydroxychloroquine , Quinine derivatives
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Faculty of Chemistry, Karaganda Buketov University, 28 Universitetskaya Str., Karaganda, 100028, Kazakhstan
Department of Biochemistry, Karaganda Medical University, 40 Gogol Str., Karaganda, 100008, Kazakhstan
Faculty of Chemistry
Department of Biochemistry
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