Synthesis and Biological Activity of Novel Polyazaheterocyclic Derivatives of Quinine
Mukusheva G.K. Toigambekova N.N. Seidakhmetova R.B. Jalmakhanbetova R.I. Babakhanova M.N. Nurkenov O.A. Akishina E.A. Dikusar E.A. Kolesnik I.A. Zhou H. Potkin V.I.
August 2025Multidisciplinary Digital Publishing Institute (MDPI)
Molecules
2025#30Issue 15
A synthetic methodology of the CuAAC “click” approach was exploited for the construction of 1,2-azolyltriazole quinine derivatives by the reaction of O-propargylquinine with azidomethyl-1,2-azoles in methanol. Quinine–piperidine and quinine–anabasine conjugates were obtained using a chloroacetate linker by reacting quinine chloroacetate with piperidine or anabasine in a diethyl ether medium. Cinchophene ester was obtained by the acylation of quinine with cinchophen acid chloride in methylene chloride. The antibacterial, fungicidal, analgesic and cytotoxic properties of the obtained compounds were examined.
anabasine , azide-alkyne cycloaddition , cinchophen , esters , isothiazole , isoxazole , methyl iodides , quinine , triazole
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Chemistry Faculty, Karaganda Buketov University, Karaganda, 100024, Kazakhstan
Department of Clinical Pharmacology and Evidence-Based Medicine, Karaganda Medical University, Karaganda, 100024, Kazakhstan
Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Astana, 010000, Kazakhstan
Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda, 100008, Kazakhstan
Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Minsk, 220072, Belarus
College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing, 314001, China
Chemistry Faculty
Department of Clinical Pharmacology and Evidence-Based Medicine
Faculty of Natural Sciences
Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan
Institute of Physical Organic Chemistry
College of Biological
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