Quinine Esters with 1,2-Azole, Pyridine and Adamantane Fragments
Mukusheva G.K. Zhasymbekova A.R. Seidakhmetova R.B. Nurkenov O.A. Akishina E.A. Petkevich S.K. Dikusar E.A. Potkin V.I.
June-1 2022MDPI
Molecules
2022#27Issue 11
An efficient method of producing quinine derivatives via reaction of acylation with 4,5-dichloroisothiazole-3-, 5-arylisoxazole-3-, adamantane-and hydrochlorides of pyridine-3-and pyridine-4-carbonyl chlorides was developed. All synthesized compounds were tested for antiviral, antimicrobial and analgesic activity. The most pronounced antibacterial activity was shown by the compounds 2e, 3b, 3c and 3e with isoxazole and pyridine fragments. It was found that most of the tested compounds showed significant analgesic activity reducing the pain response of animals to the irritating effect of acetic acid.
adamantane , analgesic activity , antimicrobial activity , antiviral activity , esters , isothiazole , isoxazole , pyridine , quaternary pyridinium salts , quinine
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Karaganda Buketov University, Karaganda, 100024, Kazakhstan
Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda, 100008, Kazakhstan
Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Minsk, 220072, Belarus
Karaganda Buketov University
Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan
Institute of Physical Organic Chemistry
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