Vitiligo: advances in pathophysiology research and treatment development
Mukhatayev Z. Le Poole I.C.
September 2024Elsevier Ltd
Trends in Molecular Medicine
2024#30Issue 9844 - 862 pp.
The autoimmune condition vitiligo, characterized by skin depigmentation, presents challenges for effective treatment design, with Janus kinase (JAK) inhibitors and other repurposed drugs offering a promising strategy for symptom management. This review explores advantages and shortcomings of current therapies, while presenting the urgent need for further innovative approaches. We emphasize the growing understanding of autoimmune involvement in vitiligo, highlighting several novel treatment avenues including relieving melanocyte stress, preventing dendritic cell activation, halting T cell migration, and suppressing inflammation and autoimmunity. Integrating psychodrama therapy to remediate stress alongside medical interventions marks a holistic approach to enhance patient well-being. The molecular underpinnings of vitiligo care are covered, emphasizing exciting advances revolutionizing vitiligo treatment and improving the quality of life for affected individuals.
autoimmunity , skin , therapy , vitiligo
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National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan
Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States
National Laboratory Astana
Department of Dermatology
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