Real-time optical in-vivo thermo-viscoelastometry of albumen and blood vessels in chicken embryo models under laser heating and ablation
Mukhangaliyeva L. Alisherov S. Bessonov V. Ashikbayeva Z. Molardi C. Tosi D. Utegulov Z.
October 2025Elsevier Ltd
Optics and Lasers in Engineering
2025#193
The laser ablation technique is commonly used in biomedicine to treat tumor cancerous tissues with minimal invasiveness to surrounding normal tissues. However, an accurate non-contact, real-time, in-situ, label-free thermomechanical measurement of affected tissues undergoing laser heating and ablation is virtually non-existent in clinical settings. In this work, we demonstrate real-time monitoring of local temperature and viscoelastic response of the albumen and blood vessels in chick chorioallantoic membrane (CAM) models during infrared laser heating and ablation by non-contact, label-free Brillouin light scattering (BLS) spectroscopy and fiber Bragg grating (FBG)-based thermal mapping. The albumen and CAM models were selected as ethical and cost-effective models with an easily accessible vasculature network to investigate changes in thermal and viscoelastic properties during laser-induced heating and ablation. Both studied biomaterials became stiffer and less viscous during laser-induced heating due to the thermal denaturation of proteins, forming cross-links with subsequent gelation (coagulation) and water evaporation (dehydration). Demonstrated hybrid BLS-FBG modality has a strong potential to equip conventional laser ablation therapy with accurate, real-time thermomechanical property-informed diagnostics to substantially improve patient outcomes.
Biomechanics , Brillouin , Fiber optics , Sensors , Spectroscopy , Thermometry
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Laboratory of Biosensors and Bioinstruments, National Laboratory Astana, Astana, 010000, Kazakhstan
Department of Electrical and Computer Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Astana, 010000, Kazakhstan
Department of Physics, School of Sciences and Humanities, Nazarbayev University, Astana, 010000, Kazakhstan
Department of Chemistry, School of Sciences and Humanities, Nazarbayev University, Astana, 010000, Kazakhstan
Laboratory of Biosensors and Bioinstruments
Department of Electrical and Computer Engineering
Department of Physics
Department of Chemistry
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