Potential compound from herbal food of Rhizoma Polygonati for treatment of COVID-19 analyzed by network pharmacology: Viral and cancer signaling mechanisms
Mu C. Sheng Y. Wang Q. Amin A. Li X. Xie Y.
February 2021Elsevier Ltd
Journal of Functional Foods
2021#77
Rhizoma Polygonati (huangjing in Chinese, 黄精) is a medicine food homology herb used as a component of traditional Chinese medicine treating COVID-19 in the current pandemic emergency in China but the mechanisms remain elusive. Here using TCMSP and Swiss Target Prediction databases to sort out the potential targets of the main chemical components and GenCLiP3, NCBI, and GeneCard databases to search for COVID-19 related targets, the chemical compound-target-pathway network was analyzed. Each component was molecularly docked with host cell target angiotensin converting enzyme II, SARS-CoV-2 targets Spike protein, RNA-dependent RNA polymerase, or 3CL hydrolase. Our results showed a higher affinity of the compound diosgenin and (+)-Syringaresinol-O-beta-D-glucoside binding to the three SARS-CoV-2 proteins compared to the other compounds tested. Thus, our data suggest that potential compounds in Rhizoma Polygonati may act on different targets with viral and cancer related signaling and have a great potential in treatment of COVID-19.
COVID-19 , Molecular docking , Network pharmacology , New coronavirus pneumonia , Rhizoma polygonati
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State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Daizong Street 61, Taian, 271018, China
College of Life Science, Northeast Agricultural University, Harbin, 150030, China
Taian Xianlu Food Co. Ltd., Taian, China
Biology Department, UAE University, Al Ain, 15551, United Arab Emirates
Biology Department, School of Sciences and Humanities, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan
Sino-German Joint Research Center for Agricultural Biology, College of Life Sciences, Shandong Agricultural University, Daizong Street 61, Taian, 271018, China
State Key Laboratory of Crop Biology
College of Life Science
Taian Xianlu Food Co. Ltd.
Biology Department
Biology Department
Sino-German Joint Research Center for Agricultural Biology
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