Endometrial thickness and live birth rates after IVF: a systematic review

Moshkalova G. Karibayeva I. Kurmanova A. Mamedalieva N. Aimbetova A. Terlikbayeva A. Mamutova A. Yerzhan Z. Yerkenova S. Zheksembay B.
14 June 2023 Mattioli 1885

Acta Biomedica
2023 #94 Issue 3

Aim: This study aims to systematically review the current literature on published studies with data on the clinical significance of endometrial thickness on ultrasound for live birth rate (LBR) after in vitro fertilization (IVF) procedures. Methods: A comprehensive systematic review of PubMed, Web of Science, ScienceDirect, Google Scholar, and Open Gray databases and a subsequent hand search of the reference list of included studies was performed. Results: We found 20 eligible studies that evaluated 20 546 patients for endometrial thickness, presented risk factors for decreased endometrial receptivity, and IVF outcomes with fresh and frozen embryo transfer (FET) cycles. The mean age of the patients ranged from 28.86 to 41.03 years. Reported endometrial thickness ranged from <4 mm to >15 mm. The clinical pregnancy rate varied from 9,09% to 61,49% in fresh embryo transfer cycles and from 13,3% to 79,31% in FET cycles. Overall, LBR varied between 4,80% and 48,99% in fresh embryo cycles and between 6.06% and 39,19% in FET cycles. Limitations. Only English-language studies were included; most studies were from the China region; retrospective study design used in most studies; different ET thresholds, which in turn could significantly alter the correlation with pregnancy outcomes; different IVF procedure protocols in fresh or FET cycles. Conclusions: IVF outcomes in patients with impaired endometrial receptivity do not depend only on the condition of the endometrium. Risk factors and endometrial thickness significantly affect LBR in fresh and FET cycles. (www.actabiomedica.it).

endometrial thickness , ICSI , IVF , live birth rate , systematic review

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Department of Medicine, Kazakhstan’s Medical University “KSPH”, Almaty, Kazakhstan
Department of Public Health, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Medicine, Al Farabi Kazakh National University, Almaty, Kazakhstan
Department of Medicine, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Science, Scientific Center for Obstetrics, Gynecology and Perinatology Almaty, Kazakhstan
Department of propaedeutics and internal diseases, Akhmet Yassawi International Kazakh-Turkish University, Turkestan, Kazakhstan
Department of Medicine, National Educational Institution “Kazakhstan-Russian Medical University”, Almaty, Kazakhstan
Department of General Medicine, Karaganda Medical University, Karaganda, Kazakhstan

Department of Medicine
Department of Public Health
Department of Medicine
Department of Medicine
Department of Science
Department of propaedeutics and internal diseases
Department of Medicine
Department of General Medicine

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