STUDY OF THE CHEMICAL COMPONENTS OF CO2 EXTRACTS FROM THE FRUITS OF SORBUS AUCUPARIA L.
Mombekov S. Datkhayev U. Dosmagulova K. Kozhamzharova A. Baidullayeva A. Mukhamejan A. Kantureyeva A. Yessimsiitova Z. Yussayeva D. Beken Z. Kydyrkhanova A. Karbozova A. Zhuravel I.
30 April 2024Technology Center
ScienceRise: Pharmaceutical Science
2024#48Issue 283 - 89 pp.
The article presents the results of the study of the chemical composition of Sorbus aucuparia L. СО2 subcritical extract. For the first time in Kazakhstan, 20 grams of brown Sorbus aucuparia L. extract were collected using subcritical carbon dioxide extraction. The current study was directed mainly to the chemical compositions of subcritical Sorbus aucuparia L. СО2 subcritical extract. The Sorbus aucuparia L. extract’s chemical compositions were determined using gas chromatography/mass spectrophotometry (GC-MS). The extract included the following main compounds: 5-Methyl-2(3H)-furanone (30.18 %), 5-(3-Ethoxy-4,5-dihydro-isoxazol-5-yl)-5-methyl-imidazolidine-2,4-dione (3.20 %), 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl (2.53 %). Determined fatty acid profile and the moisture content of raw vegetable ingredients of Sorbus substance. Quantitative determination of fatty acids of ethanol extract was carried out. The results of the analysis for fatty acids in the study showed that linoleic (37.7 %) and oleic (50.5 %) were the most prominent fatty acids. The aim of this study is to determine the component composition by using the GC-MS method and fatty acid to study the Sorbus aucuparia L. extract obtained by СО2 extraction, which grows in Kazakhstan. Materials and methods. To determine the possibility of using Sorbus aucuparia L., we carried out the composition and fatty acid of the extract obtained by СО2 extraction in subcritical conditions of Sorbus aucuparia L. by a certain GC-MS method. Results. The raw materials of the plant were collected in accordance with GACP requirements. Conducted subcritical СО2 extraction of plant raw materials showed a 20 g extraction yield. Chemical compounds were discovered, bioactive components were identified, such as 5-Methyl-2(3H)-furanone (30.18 %), 5-(3-Ethoxy-4,5-dihydro-isoxazol-5-yl)-5-methyl-imidazolidine-2,4-dione (3.20 %), 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl (2.53 %). Conclusions. The possibility of using the obtained СО2 extract of Sorbus aucuparia L. in the field of pharmaceutical products as a substance and a drug.
fatty acid , GC-MS analysis , Sorbus aucuparia L. , СО2 extraction
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School of Pharmacy, S. D. Asfendiyarov Kazakh National Medical University, Tolebi str., 94, Almaty, 050000, Kazakhstan
Faculty of Natural Science and Informatization, Arkalyk State Pedagogical Institute named after I. Altynsarin, Auelbekova str., 17, Arkalyk, 110300, Kazakhstan
Department of Engineering Disciplines and Good Practices, School of Pharmacy, S. D. Asfendiyarov Kazakh National Medical University, Tolebi str., 94, Almaty, 050000, Kazakhstan
Al-Farabi Kazakh National University, Al-Farabi ave., 71, Almaty, 050040, Kazakhstan
Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Al-Farabi ave., 71, Almaty, 050040, Kazakhstan
Department of Biological Chemistry, S. D. Asfendiyarov Kazakh National Medical University, Tolebi str., 94, Almaty, 050000, Kazakhstan
Department of Biodiversity and Bioresources, Faculty of Biology and Biotechnology, AlFarabi Kazakh National University, Al-Farabi ave., 71, Almaty, 050040, Kazakhstan
Department of Pharmaceutical Technology, Standardization and Certification of Medicines, National University of Pharmacy, Pushkinska str., 53, Kharkiv, 61002, Ukraine
School of Pharmacy
Faculty of Natural Science and Informatization
Department of Engineering Disciplines and Good Practices
Al-Farabi Kazakh National University
Faculty of Biology and Biotechnology
Department of Biological Chemistry
Department of Biodiversity and Bioresources
Department of Pharmaceutical Technology
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