Study Of Acute And Subacute Toxicity Substances With Antifungal Action Based On Pomyferin From Fruits Maclura Aurantiaca
Mombekov S.
2025V.I. Vernadsky Taurida National University
Phytotherapy Journal
2025#2025Issue 1184 - 190 pp.
Actuality. The study of the toxicity and biological activity of pomyferin, a compound derived from the fruits of Maclura aurantiaca, is crucial for the further development of effective and safe pharmaceuticals. This research also contributes to expanding our knowledge of potential applications of plant-based compounds in medicine. Aim. The primary objective of this study was to investigate the pharmacological properties of pomyferin from the fruits of Maclura aurantiaca, with a focus on evaluating its acute and subacute toxicity. Materials and methods. The acute toxicity of the pomyferin extract was studied following the guidelines approved by the Pharmacological Committee of the Republic of Kazakhstan. The experiments involved male and female white mice, each weighing between 18.0 and 22.0 grams. The mice were kept on a standard diet and housed in a vivarium under controlled conditions. Each experimental group consisted of six animals. Results. The results demonstrated no pathological changes in the general health indicators of the mice during the entire study period. The animals in all groups remained active, and no signs of intoxication or alterations in respiratory, cardiovascular, or central nervous system functions were observed. Conclusions. Based on the findings, it was concluded that the animals treated with the pomyferin substance showed no differences from the control group. The treated animals were active, displayed normal reflexes, and had regular water and food intake, with no impairment in their natural functions. Therefore, pomyferin is considered a low-toxicity substance (hazard class IV) and holds promise for further clinical studies.
fluconazole , maclura aurantiaca , pomyferin , substance
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JSC “Scientific Center for Anti-infectious Drugs”, Al-Farabi str., 75a, Kazakhstan, Almaty, 50000, Kazakhstan
JSC “Scientific Center for Anti-infectious Drugs”
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