Terbium-doped carbon dots (Tb-CDs) as a novel contrast agent for efficient X-ray attenuation

Molkenova A. Serik L. Ramazanova A. Zhumanova K. Duisenbayeva B. Zhussupbekova A. Zhussupbekov K. Shvets I.V. Kim K.S. Han D.-W. Atabaev T.S.
16 May 2023 Royal Society of Chemistry

RSC Advances
2023 #13 Issue 22 14974 - 14979 pp.

Metal-doped carbon dots have attracted considerable attention in nanomedicine over the last decade owing to their high biocompatibility and great potential for bioimaging, photothermal therapy, and photodynamic therapy. In this study, we prepared, and for the first time, examined terbium-doped CDs (Tb-CDs) as a novel contrast agent for computed tomography. A detailed physicochemical analysis revealed that the prepared Tb-CDs have small sizes (∼2-3 nm), contain relatively high terbium concentration (∼13.3 wt%), and exhibit excellent aqueous colloidal stability. Furthermore, preliminary cell viability and CT measurements suggested that Tb-CDs exhibit negligible cytotoxicity toward L-929 cells and demonstrate high X-ray absorption performance (∼48.2 ± 3.9 HU L g⁻¹). Based on these findings, the prepared Tb-CDs could serve as a promising contrast agent for efficient X-ray attenuation.

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Institute of Advanced Organic Materials, Pusan National University, Busan, 46241, South Korea
Department of Chemistry, Nazarbayev University, Astana, 010000, Kazakhstan
Department of Biology, University of Padua, Padua, 35121, Italy
Department of Radiology, Republican Diagnostic Center, Astana, 010000, Kazakhstan
School of Physics, Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Trinity College Dublin, Dublin, Ireland
Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, 46241, South Korea
School of Chemical Engineering, College of Engineering, Pusan National University, 2 Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan, 46241, South Korea
Department of Organic Material Science & Engineering, Pusan National University, 2 Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan, 46241, South Korea

Institute of Advanced Organic Materials
Department of Chemistry
Department of Biology
Department of Radiology
School of Physics
Department of Cogno-Mechatronics Engineering
School of Chemical Engineering
Department of Organic Material Science & Engineering

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