Designing inorganic nanoparticles into computed tomography and magnetic resonance (CT/MR) imaging-guidable photomedicines
Molkenova A. Atabaev T.S. Hong S.W. Mao C. Han D.-W. Kim K.S.
June 2022Elsevier Ltd
Materials Today Nano
2022#18
The recent decade has witnessed tremendous advances in therapeutic approaches for combating cancer. In particular, the emergence of nanotechnology has unlocked novel research opportunities for precision and personalized photomedicine. New multifunctional theranostic nanoplatforms have been actively investigated to accurately assess tumor parameters (location, size, and shape) for delivering appropriate therapy. Among these nanoplatforms, inorganic nanoparticles have garnered enormous attention from many research groups owing to their tailorable morphology (size, shape, porosity, etc.) and physicochemical (optical, magnetic, catalytic, X-ray opacity, etc.) characteristics. This review highlights the recent research endeavors on expanding the imaging frontiers of inorganic nanoparticles along with simultaneous cancer phototherapy. We extensively explored and critically analyzed literature published on the integration of the most commonly applied imaging modalities, such as computed tomography and magnetic resonance imaging, into inorganic nanoparticles for imaging-guided phototherapy. This review ends with a description of the future perspectives in developing imaging-guidable photomedicines with potential clinical applications.
Computed tomography (CT) , Inorganic nanoparticles , Magnetic resonance imaging (MRI) , Photodynamic therapy (PDT) , Photothermal therapy (PTT) , Synergistic PTT/PDT
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BIO-IT Fusion Technology Research Institute, Pusan National University, Busan, 46241, South Korea
Department of Chemistry, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan
Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, 46241, South Korea
Department of Chemistry and Biochemistry, University of Oklahoma, Norman, 73019, OK, United States
School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310027, China
School of Chemical Engineering, Pusan National University, Busan, 46241, South Korea
Department of Organic Materials Science and Engineering, Pusan National University, Busan, 46241, South Korea
Institute of Advanced Organic Materials, Pusan National University, Busan, 46241, South Korea
BIO-IT Fusion Technology Research Institute
Department of Chemistry
Department of Cogno-Mechatronics Engineering
Department of Chemistry and Biochemistry
School of Materials Science and Engineering
School of Chemical Engineering
Department of Organic Materials Science and Engineering
Institute of Advanced Organic Materials
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