Enhanced Mandibular Bone Repair Using Poly Lactic-co-glycolic Acid Combined with Nanohydroxyapatite Scaffold Loaded by Mesenchymal Stromal/Stem Cells and Curcumin in Male Rats
Mokhtarzadegan M. Amini S. Iraji A. Kian M. Irajie C. Sajad Daneshi S. Abbaspour S. Zare S. Jamshidzadeh A. Feiz A. Mussin N.M. Tanideh N. Tamadon A.
11 November 2024American Chemical Society
ACS Biomaterials Science and Engineering
2024#10Issue 117043 - 7053 pp.
This study aimed to investigate the healing effect of a polylactic-co-glycolic acid (PLGA) scaffold containing nanohydroxyapatite (NHA) along with curcumin (CCM), loaded with adipose-derived mesenchymal stem cells (AD-MSCs), on mandibular bone defects. The designed PLGA scaffolds containing NHA were evaluated for their mechanical and structural properties. Forty rats were divided into five groups (n = 8) based on the treatment: Sham, PLGA scaffolds containing NHA, PLGA scaffolds containing NHA + CCM, PLGA scaffolds containing NHA + AD-MSCs, and PLGA scaffolds containing NHA + CCM + AD-MSCs. After 8 weeks’ follow-up, mandible bones were isolated for histomorphometry evaluation. Data were analyzed using SPSS version 21, with p-values <0.05 considered statistically significant. SEM evaluation showed that the designed nanocomposite scaffold had 80% porosity. Histomorphometry results indicated a significant difference in osteocyte, osteoblast, bone area, and vascular area parameters in the group treated with scaffolds loaded with AD-MSCs + CCM compared to the other groups (p < 0.05). The PLGA-containing NHA-CCM nanocomposite scaffold demonstrated good porosity and dispersion, suitable for treating bone defects. Rats treated with scaffolds containing AD-MSCs and CCM showed better therapeutic results than the other groups. Further research is needed to evaluate its anti-inflammatory, antioxidant properties, osteogenesis, and therapeutic effects in larger animal models.
adipose tissue-derived mesenchymal stem cells , animal model , bone defect , CCM , polylactic-co-glycolic acid (PLGA)
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School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, Tehran, 14176-14411, Iran
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, 71348-43638, Iran
Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, 71946-84471, Iran
Central Research Laboratory, Shiraz University of Medical Sciences, Shiraz, 71946-84471, Iran
Department of Comparative Biomedical Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Fars, Shiraz, 71946-84471, Iran
Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, 71946-84471, Iran
Department of Chemical & Polymer Engineering, Faculty of Engineering, Yazd University, Yazd, 89195-741, Iran
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, 71946-84471, Iran
Department of Pharmacology-Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, 71946-84471, Iran
Department of Material Science and Engineering, Shiraz University, Shiraz, 71348-51154, Iran
Department of Surgery No. 2, West Kazakhstan Marat Ospanov Medical University, Aktobe, 030012, Kazakhstan
Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, 71946-84471, Iran
PerciaVista R&D Co., Shiraz, 71356-44144, Iran
Department of Natural Sciences, West Kazakhstan Marat Ospanov Medical University, Aktobe, 030012, Kazakhstan
School of Metallurgy and Materials Engineering
Student Research Committee
Stem Cells Technology Research Center
Central Research Laboratory
Department of Comparative Biomedical Sciences
Department of Medical Biotechnology
Department of Chemical & Polymer Engineering
Pharmaceutical Sciences Research Center
Department of Pharmacology-Toxicology
Department of Material Science and Engineering
Department of Surgery No. 2
Department of Pharmacology
PerciaVista R&D Co.
Department of Natural Sciences
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