Maleimide-Decorated PEGylated Mucoadhesive Liposomes for Ocular Drug Delivery
Moiseev R.V. Kaldybekov D.B. Filippov S.K. Radulescu A. Khutoryanskiy V.V.
15 November 2022American Chemical Society
Langmuir
2022#38Issue 4513870 - 13879 pp.
Liposomes are promising spherical vesicles for topical drug delivery to the eye. Several types of vesicles were formulated in this study, including conventional, PEGylated, and maleimide-decorated PEGylated liposomes. The physicochemical characteristics of these liposomes, including their size, zeta potential, ciprofloxacin encapsulation efficiency, loading capacity, and release, were evaluated. The structure of these liposomes was examined using dynamic light scattering, transmission electron microscopy, and small angle neutron scattering. The ex vivo corneal and conjunctival retention of these liposomes were examined using the fluorescence flow-through method. Maleimide-decorated liposomes exhibited the best retention performance on bovine conjunctiva compared to other types of liposomes studied. Poor retention of all liposomal formulations was observed on bovine cornea.
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Reading School of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6DX, United Kingdom
Department of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Forschungszentrum Jülich GmbH, Jülich Centre for Neutron Science (JCNS), Heinz Maier-Leibnitz Zentrum (MLZ), Lichtenbergstraße 1, Garching, 85748, Germany
Reading School of Pharmacy
Department of Chemistry and Chemical Technology
Forschungszentrum Jülich GmbH
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