Identifying Key Biomarkers in Pediatric Pulmonary Hypertension: An Investigative Approach
Mindubayeva F. Akhmaltdinova L. Ospanova M. Tukbekova B. Bolatbekuly Z. Niyazova Y. Salikhova Y. Avdienko O. Akhmetova M.
June 2024Multidisciplinary Digital Publishing Institute (MDPI)
Children
2024#11Issue 6
This study assesses the utility of early biomarkers—5-hydroxyindoleacetic acid (5-HIAA) and insulin-like growth factor 1 (IGF-1)—for diagnosing and monitoring pulmonary hypertension (PH) in children with congenital heart defects (CHD). Due to the risks associated with invasive diagnostics, such as right heart catheterization, non-invasive biomarkers provide a safer alternative for early PH detection. This cohort-based study utilized blood and urine samples to measure 5-HIAA and IGF-1 levels via enzyme immunoassays. Our findings revealed significant changes in 5-HIAA concentrations across various biological matrices, supporting its potential as a diagnostic tool. Specifically, altered levels in urine and plasma reflect its role in serotonin metabolism and vascular remodeling in PH. IGF-1 levels were notably reduced in plasma, suggesting its involvement in PH pathophysiology. ROC analysis confirmed the diagnostic efficacy of these biomarkers, particularly 5-HIAA’s high specificity and sensitivity. In conclusion, 5-HIAA and IGF-1 levels correlate well with PH, underscoring their diagnostic value for early PH detection in children with CHD.
5-hydroxyindoleacetic acid , children , congenital heart defects , insulin-like growth factor 1 , pulmonary hypertension
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Department of Physiology, NCJSC «Karaganda Medical University», Karaganda, 100000, Kazakhstan
Scientific Research Laboratory, NCJSC «Karaganda Medical University», Karaganda, 100000, Kazakhstan
Department of Pediatrics and Neonatology, NCJSC «Karaganda Medical University», Karaganda, 100000, Kazakhstan
Municipal State Enterprise «Multiprofile Hospital No. 2 of Karaganda», Health Department of the Karaganda Region, Karaganda, 100000, Kazakhstan
Department of Physiology
Scientific Research Laboratory
Department of Pediatrics and Neonatology
Municipal State Enterprise «Multiprofile Hospital No. 2 of Karaganda»
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