Prevalence and Potential Risk Factors of Helicobacter pylori Infection among Asymptomatic Individuals in Kazakhstan

Mezmale L. Polaka I. Rudzite D. Vangravs R. Kikuste I. Parshutin S. Daugule I. Tazhedinov A. Belikhina T. Igissinov N. Park J.Y. Herrero R. Leja M.
2021 Asian Pacific Organization for Cancer Prevention

Asian Pacific Journal of Cancer Prevention
2021 #22 Issue 2 597 - 602 pp.

Background: Helicobacter pylori (H. pylori) infection is associated with several risk factors such as demographic, socioeconomic status and personal habits, which vary in different populations. This is the most up-to-date data on H. pylori prevalence and potential risk factors for H. pylori infection among asymptomatic middle-aged individuals in Kazakhstan. Methods: Apparently healthy individuals aged 40 to 64, who took part in the health control in the outpatient clinic, were invited to participate in the study; answered a questionnaire, donated a blood sample. The antibodies to H. pylori were analysed by latex agglutination method. The baseline characteristics of study subjects with or without H. pylori infection were compared using the Chi-square test. Odds ratio (OR) and 95% confidence intervals (CI) for the association between H. pylori infection and potential risk factors were estimated using multivariable logistic regression models. Results: Altogether 166 subjects (59% male; the median age - 51 years old) were included; 104 (62.7%) were H. pylori positive. There were no statistically significant differences between H. pylori positive and H. pylori negative groups in respect to the gender, anthropometric measurements, socioeconomic factors and personal habits. The multiple variable analysis showed that age (OR, 1.99; 95% CI, 1.03 – 3.86; P=0.04) and increased salt intake (OR, 2.21; 95% CI, 1.12 – 4.35; P=0.02) were associated with H. pylori infection. Conclusions: More than half of the study subjects were infected with H. pylori in Kazakhstan. The prevalence of H. pylori infection was independently associated with older age and regular high salt consumption.

gastric cancer , Helicobacter pylori , Kazakhstan , prevalence , risk factors

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Institute of Clinical and Preventive Medicine, University of Latvia, Riga, Latvia
Faculty of Medicine, University of Latvia, Latvia
Digestive Disease Centre GASTRO, Riga, Latvia
Regional Diagnostic Centre, Almaty, Kazakhstan
Semey Regional Oncology Centre, Semey, Kazakhstan
Astana Medical University, Nur-Sultan, Kazakhstan
nternational High School of Medicine, Bishkek, Kyrgyzstan
Central Asian Cancer Institute, Nur-Sultan, Kazakhstan
Eurasian Institute For Cancer Research, Bishkek, Kyrgyzstan

Institute of Clinical and Preventive Medicine
Faculty of Medicine
Digestive Disease Centre GASTRO
Regional Diagnostic Centre
Semey Regional Oncology Centre
Astana Medical University
nternational High School of Medicine
Central Asian Cancer Institute
Eurasian Institute For Cancer Research

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